Int J Med Sci 2017; 14(11):1080-1087. doi:10.7150/ijms.20452 This issue Cite

Research Paper

Serum 1,25-dihydroxyvitamin D Better Reflects Renal Parameters Than 25-hydoxyvitamin D in Patients with Glomerular Diseases

Sungjin Chung1, 2, Minyoung Kim1, Eun Sil Koh1, Hyeon Seok Hwang1, Yoon Kyung Chang1, Cheol Whee Park1, Suk Young Kim1, Yoon Sik Chang1, Yu Ah Hong1✉

1. Division of Nephrology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea;
2. Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA.

Citation:
Chung S, Kim M, Koh ES, Hwang HS, Chang YK, Park CW, Kim SY, Chang YS, Hong YA. Serum 1,25-dihydroxyvitamin D Better Reflects Renal Parameters Than 25-hydoxyvitamin D in Patients with Glomerular Diseases. Int J Med Sci 2017; 14(11):1080-1087. doi:10.7150/ijms.20452. https://www.medsci.org/v14p1080.htm
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Abstract

Background: Impaired vitamin D metabolism may contribute to the development and progression of chronic kidney disease. The purpose of this study was to determine associations of circulating vitamin D with the degree of proteinuria and estimated glomerular filtration rate (eGFR) in patients with biopsy-proven glomerular diseases.

Methods: Clinical and biochemical data including blood samples for 25-hydroxyvitamin D (25(OH)D) and 1,25-dihydroxyvitamin D (1,25(OH)2D) levels were collected from patients at the time of kidney biopsy.

Results: Serum 25(OH)D levels were not different according to eGFR. However, renal function was significantly decreased with lower serum 1,25(OH)2D levels (P < 0.001). The proportions of nephrotic-range proteinuria and renal dysfunction (eGFR ≤ 60 mL/min/1.73 m2) progressively increased with declining 1,25(OH)2D but not 25(OH)D. Multivariable linear regression analysis showed that 25(OH)D was significantly correlated with serum albumin and total cholesterol (β = 0.224, P = 0.006; β = -0.263, P = 0.001) and 1,25(OH)2D was significantly correlated with eGFR, serum albumin and phosphorus (β = 0.202, P = 0.005; β = 0.304, P < 0.001; β = -0.161, P = 0.024). In adjusted multivariable linear regression, eGFR and 24hr proteinuria were independently correlated only with 1,25(OH)2D (β = 0.154, P = 0.018; β = -0.171, P = 0.012), but not 25(OH)D. The lower level of 1,25(OH)2D was associated with the frequent use of immunosuppressive agents (P < 0.001).

Conclusion: It is noteworthy in these results that circulating 1,25(OH)2D may be superior to 25(OH)D as a marker of severity of glomerular diseases.

Keywords: Vitamin D, Biopsy, Glomerular disease, Proteinuria, Glomerular filtration rate.


Citation styles

APA
Chung, S., Kim, M., Koh, E.S., Hwang, H.S., Chang, Y.K., Park, C.W., Kim, S.Y., Chang, Y.S., Hong, Y.A. (2017). Serum 1,25-dihydroxyvitamin D Better Reflects Renal Parameters Than 25-hydoxyvitamin D in Patients with Glomerular Diseases. International Journal of Medical Sciences, 14(11), 1080-1087. https://doi.org/10.7150/ijms.20452.

ACS
Chung, S.; Kim, M.; Koh, E.S.; Hwang, H.S.; Chang, Y.K.; Park, C.W.; Kim, S.Y.; Chang, Y.S.; Hong, Y.A. Serum 1,25-dihydroxyvitamin D Better Reflects Renal Parameters Than 25-hydoxyvitamin D in Patients with Glomerular Diseases. Int. J. Med. Sci. 2017, 14 (11), 1080-1087. DOI: 10.7150/ijms.20452.

NLM
Chung S, Kim M, Koh ES, Hwang HS, Chang YK, Park CW, Kim SY, Chang YS, Hong YA. Serum 1,25-dihydroxyvitamin D Better Reflects Renal Parameters Than 25-hydoxyvitamin D in Patients with Glomerular Diseases. Int J Med Sci 2017; 14(11):1080-1087. doi:10.7150/ijms.20452. https://www.medsci.org/v14p1080.htm

CSE
Chung S, Kim M, Koh ES, Hwang HS, Chang YK, Park CW, Kim SY, Chang YS, Hong YA. 2017. Serum 1,25-dihydroxyvitamin D Better Reflects Renal Parameters Than 25-hydoxyvitamin D in Patients with Glomerular Diseases. Int J Med Sci. 14(11):1080-1087.

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