25 March 2018
Int J Med Sci 2017; 14(9):896-901. doi:10.7150/ijms.19933
Amelioration of estrogen-deficiency-induced obesity by Ocimum gratissimum
1. Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan
Objectives: Menopausal transition in women initiates with declining estrogen levels and is followed by significant changes in their physiological characteristics. These changes often lead to medical conditions, such as obesity, which is correlated with chronic low-grade/subclinical inflammation. Ocimum gratissimum L. is a food spice or traditional herb in many countries; the plant is rich in antioxidants, which possess anti-inflammation activities and multitude of other therapeutic functions.
Methods: In this study, we evaluated effects of O. gratissimum extract (OGE) in preventing obesity by using ovariectomized (OVX) animal models to mimic menopausal women.
Methods: OVX rats showed increase in body weight and in adipocyte size in perigonadal adipose tissue (p <0.05) and decrease in uterus weight. By contrast, OGE (0.2 mg/ml) significantly reduced body weight gain and adipocyte in OVX rats and showed insignificant changes in uterus weight. Further investigation indicated that OGE exerted no influence on levels of dorsal fat, serum total cholesterol, and serum triacylglycerol and on serum biochemical factors, calcium, phosphorus, and glucose.
Conclusion: These findings suggested that OGE dietary supplements may be useful in controlling body weight of menopausal women.
Keywords: Ocimum gratissimum, obesity, ovariectomized animal models
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How to cite this article:
Chao PY, Chiang TI, Chang IC, Tsai FL, Lee HH, Hsieh K, Chiu YW, Lai TJ, Liu JY, Hsu LS, Shih YC. Amelioration of estrogen-deficiency-induced obesity by Ocimum gratissimum. Int J Med Sci 2017; 14(9):896-901. doi:10.7150/ijms.19933. Available from http://www.medsci.org/v14p0896.htm