19 February 2018
Int J Med Sci 2016; 13(11):819-824. doi:10.7150/ijms.16474
Ocimum gratissmum aqueous extract reduces plasma lipid in hypercholesterol-fed hamsters
1. Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan
Objectives: Hyperlipidemia is a significant risk factor in the development of atherosclerosis and related diseases which are major health problem in many developed and developing countries that can lead to fatality due to the changes in lifestyle and dietary habits in this modern age.
Methods: In the present study, the Ocimum gratissimum aqueous extract (OGE) was tested for the lowering effect on the serum lipid level of male hamsters on a high-fat (12%) and high-cholesterol (0.2%) diet (HFCD).
Results: The results showed that the levels of serum high-density-lipoprotein-cholesterol (HDL-C) low-density-lipoprotein-cholesterol (LDL-C), total cholesterol (TC), and triglycerols (TG) were increased in the HFCD group (113±11, 259±87, 629±175 and 625±262, respectively), as compared to the control normal diet group (51±8, 19±5, 77±16 and 101±44, respectively). When co-treated with various doses (10 and 20 mg/kg) of the OGE or rosuvastatin, the rats exhibited the restoration of normal serum LDL-C, TC, and TG levels.
Conclusion: Therefore, we suggest that the Ocimum gratissimum aqueous extract may have the potential function of lowering serum lipid in rats.
Keywords: Ocimum gratissimum, cholesterol, Hyperlipidemia
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How to cite this article:
Chao PY, Lin JA, Ting WJ, Lee HH, Hsieh K, Chiu YW, Lai TJ, Hwang JM, Liu Jr, Huang CY. Ocimum gratissmum aqueous extract reduces plasma lipid in hypercholesterol-fed hamsters. Int J Med Sci 2016; 13(11):819-824. doi:10.7150/ijms.16474. Available from http://www.medsci.org/v13p0819.htm