International Journal of Medical Sciences

Impact factor
2.399

14 December 2017

ISSN 1449-1907 News feeds of published articles

My Manuscript | My Account

Journal of Biomedicinenew

Theranostics

Journal of Cancer

Oncomedicine

International Journal of Biological Sciences

Journal of Genomics

Journal of Bone and Joint Infection (JBJI)

Nanotheranostics

PubMed Central Indexed in Journal Impact Factor

Int J Med Sci 2016; 13(10):749-753. doi:10.7150/ijms.16090

Research Paper

Lower Body Mass Index is a Risk Factor for In-Hospital Mortality of Elderly Japanese Patients Treated with Ampicillin/sulbactam

Makoto Miura1✉, Akiko Kuwahara2, Akinori Tomozawa3, Naoki Omae4, Motohiro Yamamori2, Kaori Kadoyama5, Toshiyuki Sakaeda5,6✉

1. Department of Pharmacy, Rakuwakai Otowa Hospital, Kyoto 607-8062, Japan;
2. School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya 663-8179, Japan;
3. Department of Pharmacy, Kyoto Kujo Hospital, Kyoto 601-8453, Japan;
4. Department of Pharmacy, Rakuwakai Marutamachi Hospital, Kyoto 604-8405, Japan;
5. Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan;
6. Department of Pharmacokinetics, Kyoto Pharmaceutical University, Kyoto 607-8414, Japan.

Abstract

Objectives: A retrospective examination was conducted to identify risk factors for in-hospital mortality of elderly patients (65 years or older) treated with the beta-lactam/beta-lactamase inhibitor combination antibiotic, ampicillin/sulbactam (ABPC/SBT).

Methods: Clinical data from 96 patients who were hospitalized with infectious diseases and treated with ABPC/SBT (9 g/day or 12 g/day) were analyzed. Risk factors examined included demographic and clinical laboratory parameters. Parameter values prior to treatment and changes after treatment were compared between survivors and non-survivors.

Results: The study patients had an average age of 81.9±8.4 years (±SD) and body mass index (BMI) of 19.9±4.2 kg/m2. They were characterized by anemia (low hemoglobin and hematocrit levels), inflammation (high leukocyte count, neutrophil count, C-reactive protein level, and body temperature), and hepatic and renal dysfunction (high aspartate aminotransferase, alanine aminotransferase and blood urea nitrogen levels). The BMI of non-survivors, 16.2±2.9 kg/m2, was lower than that of survivors, 20.4±4.1 kg/m2. In addition, the hematological parameters deteriorated more remarkably, inflammation markers were not altered (or the decrease was marginal), and hepatic function was not improved, in non-survivors.

Conclusions: A lower BMI value is a risk factor for in-hospital mortality of elderly patients treated with ABPC/SBT.

Keywords: ampicillin/sulbactam, elderly patients, mortality, body mass index.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.
How to cite this article:
Miura M, Kuwahara A, Tomozawa A, Omae N, Yamamori M, Kadoyama K, Sakaeda T. Lower Body Mass Index is a Risk Factor for In-Hospital Mortality of Elderly Japanese Patients Treated with Ampicillin/sulbactam. Int J Med Sci 2016; 13(10):749-753. doi:10.7150/ijms.16090. Available from http://www.medsci.org/v13p0749.htm