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24 April 2018 |
International Journal of Biological Sciences Journal of Bone and Joint Infection (JBJI) ![]() ![]() |
Int J Med Sci 2016; 13(8):569-577. doi:10.7150/ijms.15597 Research Paper Heat-killed Lactobacillus Reuteri GMNL-263 Prevents Epididymal Fat Accumulation and Cardiac Injury in High-Calorie Diet-Fed Rats 1. Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan High-calorie diet-induced obesity leads to cardiomyocyte dysfunction and apoptosis. Impaired regulation of epididymal fat content in obese patients has been known to increase the risk of cardiac injury. In our study, a lactic acid bacteria, Lactobacillus reuteri GMNL-263, was evaluated for its potential to reduce body weight and body fat ratio and to prevent heart injury in rats with high-fat diet-induced obesity. Lactic acid bacteria supplementation restored the cardiac function and decreased the physiological changes in the heart of the obese rats. In addition, the Fas/Fas-associated protein pathway-induced caspase 3/e Poly polymerase mediated apoptosis in the cardiomyocytes of the obese rats was reversed in the Lr263-treated rats. These results reveal that fed with Lr-263 reduces body fat ratio, inhibits caspase 3-mediated apoptosis and restores cardiac function in obese rats through recovery of ejection fraction and fractional shortening. Our results indicated that the administration of Lr263 lactic acid bacteria can significantly down-regulate body fat and prevent cardiomyocyte injury in obese rats. Keywords: Functional food, High-calorie diet, Obesity, Cardiac dysfunction This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.
How
to cite this article:
Liao PH, Kuo WW, Hsieh DJY, Yeh YL, Day CH, Chen YH, Chang SH, Padma VV, Chen YH, Huang CY. Heat-killed Lactobacillus Reuteri GMNL-263 Prevents Epididymal Fat Accumulation and Cardiac Injury in High-Calorie Diet-Fed Rats. Int J Med Sci 2016; 13(8):569-577. doi:10.7150/ijms.15597. Available from http://www.medsci.org/v13p0569.htm |