International Journal of Medical Sciences

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22 October 2017

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Int J Med Sci 2016; 13(2):147-153. doi:10.7150/ijms.13746

Research Paper

Vitamin D3 Reduces Tissue Damage and Oxidative Stress Caused by Exhaustive Exercise

Chun-Yen Ke1, Fwu-Lin Yang2, Wen-Tien Wu3, Chen-Han Chung4, Ru-Ping Lee5, Wan-Ting Yang5, Yi-Maun Subeq6✉, Kuang-Wen Liao1✉

1. Institute of Molecular Medicine and Bioengineering, National Chiao Tung University, Hsinchu, Taiwan;
2. Intensive Care Unit, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taipei, Taiwan;
3. Department of Orthopedics, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan;
4. Institute of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan;
5. Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan;
6. Department of Nursing, Tzu Chi University, Hualien, Taiwan.

Abstract

Exhaustive exercise results in inflammation and oxidative stress, which can damage tissue. Previous studies have shown that vitamin D has both anti-inflammatory and antiperoxidative activity. Therefore, we aimed to test if vitamin D could reduce the damage caused by exhaustive exercise. Rats were randomized to one of four groups: control, vitamin D, exercise, and vitamin D+exercise. Exercised rats received an intravenous injection of vitamin D (1 ng/mL) or normal saline after exhaustive exercise. Blood pressure, heart rate, and blood samples were collected for biochemical testing. Histological examination and immunohistochemical (IHC) analyses were performed on lungs and kidneys after the animals were sacrificed. In comparison to the exercise group, blood markers of skeletal muscle damage, creatine kinase and lactate dehydrogenase, were significantly (P < 0.05) lower in the vitamin D+exercise group. The exercise group also had more severe tissue injury scores in the lungs (average of 2.4 ± 0.71) and kidneys (average of 3.3 ± 0.6) than the vitamin D-treated exercise group did (1.08 ± 0.57 and 1.16 ± 0.55). IHC staining showed that vitamin D reduced the oxidative product 4-Hydroxynonenal in exercised animals from 20.6% to 13.8% in the lungs and from 29.4% to 16.7% in the kidneys. In summary, postexercise intravenous injection of vitamin D can reduce the peroxidation induced by exhaustive exercise and ameliorate tissue damage, particularly in the kidneys and lungs.

Keywords: Calcitriol, 4-Hydroxynonenal, lipid peroxidation.

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How to cite this article:
Ke CY, Yang FL, Wu WT, Chung CH, Lee RP, Yang WT, Subeq YM, Liao KW. Vitamin D3 Reduces Tissue Damage and Oxidative Stress Caused by Exhaustive Exercise. Int J Med Sci 2016; 13(2):147-153. doi:10.7150/ijms.13746. Available from http://www.medsci.org/v13p0147.htm