International Journal of Medical Sciences

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21 October 2017

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Int J Med Sci 2015; 12(12):995-999. doi:10.7150/ijms.13193

Short Research Communication

Chronic Alcohol Consumption Leads to a Tissue Specific Expression of Uncoupling Protein-2

Jan A. Graw#, Clarissa von Haefen#, Deniz Poyraz, Nadine Möbius, Marco Sifringer, Claudia D. Spies

Department of Anesthesiology and Intensive Care Medicine, Campus Charité Mitte and Campus Virchow-Klinikum, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, D-13353 Berlin, Germany
# Jan A. Graw and Clarissa von Haefen contributed equally to this work

Abstract

Uncoupling proteins (UCPs) are anion channels that can decouple the mitochondrial respiratory chain. "Mild uncoupling" of internal respiration reduces free radical production and oxidative cell stress. Chronic alcohol consumption is a potent inducer of oxidative stress in multiple tissues and regulates UCP-2 and -4 expression in the brain. To analyse the impact of chronic alcohol intake on UCP-2 expression in tissues with high endogenous UCP-2 contents, male Wistar rats (n=34) were treated with a 12-week 5% alcohol diet. In the lungs and the spleen of rats with a chronic alcohol diet cytochrome c release from mitochondria was significantly increased. Both organs did not show any altered gene and protein expression of UCP-2. Different to cerebral tissue chronic alcohol consumption has no regulatory effect on UCP-2 gene and protein expression in organs with a high endogenous UCP-2 content. Therefore, chronic alcohol consumption leads to a tissue specific expression of UCP-2.

Keywords: Chronic alcohol consumption, Uncoupling proteins, Cytochrome c, reactive oxygen species

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How to cite this article:
Graw JA, von Haefen C, Poyraz D, Möbius N, Sifringer M, Spies CD. Chronic Alcohol Consumption Leads to a Tissue Specific Expression of Uncoupling Protein-2. Int J Med Sci 2015; 12(12):995-999. doi:10.7150/ijms.13193. Available from http://www.medsci.org/v12p0995.htm