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18 March 2019

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Int J Med Sci 2015; 12(12):926-936. doi:10.7150/ijms.13267


Neurological Effects of Bisphenol A and its Analogues

Hidekuni Inadera

Department of Public Health, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan


The endocrine disrupting chemical bisphenol A (BPA) is widely used in the production of polycarbonate plastics and epoxy resins. The use of BPA-containing products in daily life makes exposure ubiquitous, and the potential human health risks of this chemical are a major public health concern. Although numerous in vitro and in vivo studies have been published on the effects of BPA on biological systems, there is controversy as to whether ordinary levels of exposure can have adverse effects in humans. However, the increasing incidence of developmental disorders is of concern, and accumulating evidence indicates that BPA has detrimental effects on neurological development. Other bisphenol analogues, used as substitutes for BPA, are also suspected of having a broad range of biological actions. The objective of this review is to summarize our current understanding of the neurobiological effects of BPA and its analogues, and to discuss preventive strategies from a public health perspective.

Keywords: Bisphenol A, Epigenetics, Neurodevelopment

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How to cite this article:
Inadera H. Neurological Effects of Bisphenol A and its Analogues. Int J Med Sci 2015; 12(12):926-936. doi:10.7150/ijms.13267. Available from