International Journal of Medical Sciences

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25 May 2019

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Int J Med Sci 2015; 12(4):295-300. doi:10.7150/ijms.11523

Research Paper

The Effects of Antenatal Corticosteroids on Short- and Long-Term Outcomes in Small-for-Gestational-Age Infants

Hiroshi Ishikawa1✉, Ken Miyazaki2, Tomoaki Ikeda3, Nao Murabayashi3, Kazutoshi Hayashi4, Akihiko Kai5, Kaoru Ishikawa6, Yoshihiro Miyamoto7, Kunihiro Nishimura7, Yumi Kono8, Satoshi Kusuda9, Masanori Fujimura10, Neonatal Research Network of Japan

1. Department of Obstetrics and Gynecology, Kanagawa Children's Medical Center
2. Department of Obstetrics and Gynecology, Japanese Red Cross Nagoya Daiichi Hospital
3. Department of Obstetrics and Gynecology, Mie University Graduate School of Medicine
4. Department of Obstetrics and Gynecology, Kochi Health Sciences Center
5. Department of Pediatrics, Aizenbashi Hospital
6. Endowed Chair for Regeneration of Medicine in Kuwana District, Suzuka university of medical science
7. Department of Preventive Medicine and Epidemiologic Informatics, National Cerebral and Cardiovascular Center
8. Department of Pediatrics, Jichi Medical University
9. Department of Neonatology, Maternal and Perinatal Center, Tokyo Women's Medical University
10. Department of Neonatology, Osaka Medical Center and Research Institute for Maternal and Child Health, Director of the Neonatal Research Network of Japan.


Aim: To evaluate the effect of antenatal corticosteroids (ANS) on short- and long-term outcomes in small-for-gestational age (SGA) infants.

Methods: A retrospective database analysis was performed. A total of 1,931 single infants (birth weight <1,500 g) born at a gestational age between 22 weeks and 33 weeks 6 days who were determined to be SGA registered in the Neonatal Research Network Database in Japan between 2003 and 2007 were evaluated for short-term outcome and long-term outcome.

Results: ANS was administered to a total of 719 infants (37%) in the short-term outcome evaluation group and 344 infants (36%) in the long-term outcome evaluation group. There were no significant differences between the ANS group and the no-ANS group for primary short-term outcome (adjusted odds ratio (OR) 0.73; 95% confidence interval (CI) 0.45-1.20; P-value 0.22) or primary long-term outcome (adjusted OR 0.69; 95% CI 0.40-1.17; P-value 0.17).

Conclusions: Our results show that ANS does not affect short- or long-term outcome in SGA infants when the birth weight is less than 1500 g. This study strongly suggests that administration of ANS resulted in few benefits for preterm FGR fetuses.

Keywords: fetal growth restriction, glucocorticoids, infant, infant mortality, premature birth, small for gestational age

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See for full terms and conditions.
How to cite this article:
Ishikawa H, Miyazaki K, Ikeda T, Murabayashi N, Hayashi K, Kai A, Ishikawa K, Miyamoto Y, Nishimura K, Kono Y, Kusuda S, Fujimura M, Neonatal Research Network of Japan. The Effects of Antenatal Corticosteroids on Short- and Long-Term Outcomes in Small-for-Gestational-Age Infants. Int J Med Sci 2015; 12(4):295-300. doi:10.7150/ijms.11523. Available from