International Journal of Medical Sciences

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21 October 2017

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Int J Med Sci 2015; 12(2):187-200. doi:10.7150/ijms.10083

Review

Nanoparticle-Based Targeted Therapeutics in Head-And-Neck Cancer

Ting-Ting Wu, Shui-Hong Zhou

Department of Otolaryngology, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, China

Abstract

Head-and-neck cancer is a major form of the disease worldwide. Treatment consists of surgery, radiation therapy and chemotherapy, but these have not resulted in improved survival rates over the past few decades. Versatile nanoparticles, with selective tumor targeting, are considered to have the potential to improve these poor outcomes. Application of nanoparticle-based targeted therapeutics has extended into many areas, including gene silencing, chemotherapeutic drug delivery, radiosensitization, photothermal therapy, and has shown much promise. In this review, we discuss recent advances in the field of nanoparticle-mediated targeted therapeutics for head-and-neck cancer, with an emphasis on the description of targeting points, including future perspectives.

Keywords: Nanoparticles, targeted therapeutics, head-and-neck cancer, RNA interference, drug delivery, radiosensitization, photothermal therapy

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.
How to cite this article:
Wu TT, Zhou SH. Nanoparticle-Based Targeted Therapeutics in Head-And-Neck Cancer. Int J Med Sci 2015; 12(2):187-200. doi:10.7150/ijms.10083. Available from http://www.medsci.org/v12p0187.htm