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Int J Med Sci 2014; 11(12):1218-1227. doi:10.7150/ijms.9975

Research Paper

Whole-Body Vibration Training Effect on Physical Performance and Obesity in Mice

Chi-Chang Huang1, ✉, Tzu-Ling Tseng1,#, Wen-Ching Huang2, Yi-Hsiu Chung3, Hsiao-Li Chuang4,#, Jyh-Horng Wu5, ✉

1. Graduate Institute of Sports Science, National Taiwan Sport University, Taoyuan 33301, Taiwan
2. Graduate Institute of Athletics and Coaching Science, National Taiwan Sport University, Taoyuan 33301, Taiwan
3. Molecular Imaging Center and Department of Nuclear Medicine, Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan
4. National Laboratory Animal Center, National Applied Research Laboratories, Taipei 11529, Taiwan
5. Department of Forestry, National Chung Hsing University, Taichung 40227, Taiwan
# These authors contributed equally to this work.


The purpose of this study was to verify the beneficial effects of whole-body vibration (WBV) training on exercise performance, physical fatigue and obesity in mice with obesity induced by a high-fat diet (HFD). Male C57BL/6 mice were randomly divided into two groups: normal group (n=6), fed standard diet (control), and experimental group (n=18), fed a HFD. After 4-week induction, followed by 6-week WBV of 5 days per week, the 18 obese mice were divided into 3 groups (n=6 per group): HFD with sedentary control (HFD), HFD with WBV at relatively low-intensity (5.6 Hz, 0.13 g) (HFD+VL) or high-intensity (13 Hz, 0.68 g) (HFD+VH). A trend analysis revealed that WBV increased the grip strength in mice. WBV also dose-dependently decreased serum lactate, ammonia and CK levels and increased glucose level after the swimming test. WBV slightly decreased final body weight and dose-dependently decreased weights of epididymal, retroperitoneal and perirenal fat pads and fasting serum levels of alanine aminotransferase, CK, glucose, total cholesterol and triacylglycerol. Therefore, WBV could improve exercise performance and fatigue and prevent fat accumulation and obesity-associated biochemical alterations in obese mice. It may be an effective intervention for health promotion and prevention of HFD-induced obesity.

Keywords: vibration training, exercise performance, fatigue, obesity, high fat diet

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See for full terms and conditions.
How to cite this article:
Huang CC, Tseng TL, Huang WC, Chung YH, Chuang HL, Wu JH. Whole-Body Vibration Training Effect on Physical Performance and Obesity in Mice. Int J Med Sci 2014; 11(12):1218-1227. doi:10.7150/ijms.9975. Available from