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12 December 2018

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Int J Med Sci 2014; 11(8):834-840. doi:10.7150/ijms.6961

Research Paper

Determinants of Right Ventricular Muscle Mass in Idiopathic Dilated Cardiomyopathy: Impact of Left Ventricular Muscle Mass and Pulmonary Hypertension

Julia Vormbrock1, Jeanette Liebeton1, Sophia Wirdeier1, Axel Meissner1, Thomas Butz1, Hans-Joachim Trappe1, Gunnar Plehn2 ✉

1. Department of Cardiology and Angiology, University of Bochum, Germany;
2. Department of Cardiology, Johanniter-Krankenhaus, Duisburg, Germany.


Introduction: Although chronic pulmonary hypertension and right ventricular (RV) function carry important functional and prognostic implications in idiopathic dilated cardiomyopathy (IDC), little information on RV muscle mass (RVMM) and its determinants has been published.

Methods: Our study comprised thirty-five consecutive patients with IDC, left ventricular (LV) ejection fraction <40% and NYHA class ≥2. Hemodynamic data and parameters on LV and RV geometry were derived from right heart catheterisation and cardiac magnetic resonance imaging.

Results: RVMM was normalized to body size using a common linear, body surface area based approach (RVMMI) and by an allometric index (RVMM-AI) incorporating adjustment for age, height and weight. Stepwise multiple regression analysis revealed that pulmonary artery pressure and left ventricular muscle mass were independent predictors of RVMM-AI. The interventricular mass ratio of RV and LV mass (IVRM) was closely related to RVMM (r = 0.79, p < 0.001) and total muscle mass (r = 0.39, p < 0.02). However, there was no significant relationship between LVMM and IVMR (r = 0.17, p = 0.32).

Conclusion: Our data suggest that an increase in RV mass in IDC may be explained by two mechanisms: First, as a consequence of the myopathic process itself resulting in a balanced hypertrophy of both ventricles. Second, due to the chamber specific burden of pulmonary artery pressure rise, resulting in unbalanced RV hypertrophy.

Keywords: Right ventricular muscle mass, heart failure, myocardial hypertrophy.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See for full terms and conditions.
How to cite this article:
Vormbrock J, Liebeton J, Wirdeier S, Meissner A, Butz T, Trappe HJ, Plehn G. Determinants of Right Ventricular Muscle Mass in Idiopathic Dilated Cardiomyopathy: Impact of Left Ventricular Muscle Mass and Pulmonary Hypertension. Int J Med Sci 2014; 11(8):834-840. doi:10.7150/ijms.6961. Available from