International Journal of Medical Sciences

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22 October 2017

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Int J Med Sci 2014; 11(1):87-96. doi:10.7150/ijms.7651

Research Paper

Microgravity Inhibits Resting T Cell Immunity in an Exposure Time-Dependent Manner

Haiying Luo, Chongzhen Wang, Meifu Feng, Yong Zhao

State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China

Abstract

Background: Decline immune function is well documented after spaceflights. Microgravity is one of the key factors directly suppressing the function of immune system. Though T cell immune response was inhibited by microgravity, it is not clearly whether activation would be inhibited after a pre-exposure of microgravity on T lymphocytes at the resting state. Methods: We herein investigated the response ability of resting CD4+ and CD8+ T cells experiencing pre-exposure of modeled microgravity (MMg) for 0, 8, 16 and 24 hrs to concanavalin A (ConA) stimulation. The phenotypes and subsets of immune cells were determined by flow cytometry. Results: Both CD4+ and CD8+ T cells with an MMg pre-exposure exhibited decreased expressions of activation-markers including CD25, CD69 and CD71, inflammatory cytokine secretion and cell proliferation in response to ConA compared with T cells with 1g controls in an MMg exposure time- dependent manner. Moreover, short term MMg treatment caused more severe decreased proliferation in CD4+ T cells than in CD8+ T cells. Conclusions: MMg can directly impact on resting T cell subsets. CD4+ T cells were more sensitive to the microgravity inhibition than CD8+ T cells in respect of cell proliferation. These results offered new insights for the MMg-caused T cell functional defects.

Keywords: Immune response, T cells, microgravity, proliferation, spaceflight.

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How to cite this article:
Luo H, Wang C, Feng M, Zhao Y. Microgravity Inhibits Resting T Cell Immunity in an Exposure Time-Dependent Manner. Int J Med Sci 2014; 11(1):87-96. doi:10.7150/ijms.7651. Available from http://www.medsci.org/v11p0087.htm