International Journal of Medical Sciences

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17 October 2017

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Int J Med Sci 2013; 10(12):1771-1777. doi:10.7150/ijms.7044

Research Paper

Scavenger Receptor Class B Type 1 Gene rs5888 Single Nucleotide Polymorphism and the Risk of Coronary Artery Disease and Ischemic Stroke: A Case-Control Study

Dong-Feng Wu1, Rui-Xing Yin1✉, Xiao-Li Cao2, Wu-Xian Chen1, Lynn Htet Htet Aung1, Wei Wang1, Ke-Ke Huang1, Ping Huang1, Xiao-Na Zeng1, Jian Wu1

1. Department of Cardiology, Institute of Cardiovascular Diseases, the First Affiliated Hospital, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, Guangxi, People's Republic of China
2. Department of Neurology, the First Affiliated Hospital, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, Guangxi, People's Republic of China

Abstract

Background: Our previous studies have showed that the rs5888 single nucleotide polymorphism (SNP) in Scavenger receptor class B type 1 (SCARB1) gene is associated with serum lipid levels in the general Chinese populations. The present study was undertaken to detect the associations between rs5888 SNP and the risk of coronary artery disease (CAD) and ischemic stroke (IS).

Methods: A total of 1,716 unrelated subjects (CAD, 601; IS, 533; and healthy controls, 582) were included in this study. Genotyping of the rs5888 SNP were determined by polymerase chain reaction and restriction fragment length polymorphism.

Results: The genotypic frequencies of SCARB1 rs5888 SNP were different between CAD patients and controls, the subjects with TT genotype had high risk of CAD (OR = 1.76, P = 0.038 for TT vs. CC; and OR = 1.75, P = 0.036 for TT vs. CC/CT). There was no significant association between genotypes and the risk of IS. Further analysis showed that the subjects with TT genotype in the total population had lower levels of high-density lipoprotein cholesterol than the subjects with CC/CT genotypes (P < 0.05), the subjects with TT genotype in controls but not in CAD or IS patients had higher levels of serum LDL-C and ApoB than those with CC genotype (P < 0.05 for each).

Conclusions: The present study suggests that the SCARB1 rs5888 SNP influences serum lipid levels, and is associated with the risk of CAD.

Keywords: Scavenger receptor class B type 1 gene, Single nucleotide polymorphism, Coronary artery disease, Ischemic stroke, Lipid

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How to cite this article:
Wu DF, Yin RX, Cao XL, Chen WX, Aung LHH, Wang W, Huang KK, Huang P, Zeng XN, Wu J. Scavenger Receptor Class B Type 1 Gene rs5888 Single Nucleotide Polymorphism and the Risk of Coronary Artery Disease and Ischemic Stroke: A Case-Control Study. Int J Med Sci 2013; 10(12):1771-1777. doi:10.7150/ijms.7044. Available from http://www.medsci.org/v10p1771.htm