International Journal of Medical Sciences

Impact factor

20 January 2019

ISSN 1449-1907 News feeds of published articles

Manuscript login | Account

open access Global reach, higher impact

Journal of Genomics in PubMed Central. Submit manuscript now...


Journal of Cancer

International Journal of Biological Sciences

Journal of Genomics



Journal of Biomedicine

PubMed Central Indexed in Journal Impact Factor

Int J Med Sci 2013; 10(11):1584-1588. doi:10.7150/ijms.6360

Research Paper

The Ratio of Second to Fourth Digit Length (2D:4D) and Coronary Artery Disease in a Han Chinese Population

Xing-li Wu1✉*, Ding-you Yang2*, Wen-hui Chai3, Ming-lei Jin4, Xing-chun Zhou5, Li Peng1, Yu-sheng Zhao1

1. Institute of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China.
2. Department of Traditional Chinese Medicine, the First Affiliate Hospital of Chinese PLA General Hospital, Beijing, China.
3. Department of Geriatrics, the Changji People's Hospital, Urumqi, China.
4. Department of Geriatrics, Chengde City Hospital, Hebei, China.
5. Department of Cardiology, Rongcheng City Hospital, Shandong, China.
*Authors devoted equally to this work.


Background: The association between index finger to ring finger length ratio (2D:4D) and cardiac disorders has been reported, however it has not been discussed in terms of coronary artery disease (CAD). We investigated whether 2D:4D could be used as a marker for predisposition to CAD as assessed by coronary angiography in Chinese men and women.

Methods: This study included 1764 persons divided into 4 groups, 441 cases with CAD and 441 persons without CAD as control in each sex of the same age. Finger lengths were measured twice for both hands using electronic calipers. Student t test was used to detect the difference of 2D:4D among groups. The receiver operator characteristic curves (ROCs) were used to detect the diagnostic effect of 2D:4D for CAD.

Results: There were no significant differences in age among the four groups. A significant difference of 2D:4D ratios between right and left hand were observed only in men in both control and CAD groups. On the right hand in the control group and on both hands in the CAD group, the 2D:4D ratios were higher in women than in men (all, P < 0.001). In men with CAD, mean 2D:4D was higher than mean 2D:4D in control men (right hand 0.962±0.042:0.927±0.038; left hand 0.950±0.044:0.934±0.048; both hands, P < 0.001), but this was not observed in women. No relationship was found between 2D:4D and age (all, P >0.05). The area under the curve of right hand 2D:4D in male was 0.72 (95% CI 0.683-0.753, p<0.001), while it was 0.602 (95% CI 0.565-0.639, p<0.001) in left hand.

Conclusions: The present study showed an association between high 2D:4D ratio and CAD in both hands in men. There were no significant differences in mean 2D:4D between women with CAD and controls.

Keywords: finger length ratio, 2D:4D, coronary artery disease, Chinese, coronary angiography, diagnosis.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See for full terms and conditions.
How to cite this article:
Wu Xl, Yang Dy, Chai Wh, Jin Ml, Zhou Xc, Peng L, Zhao Ys. The Ratio of Second to Fourth Digit Length (2D:4D) and Coronary Artery Disease in a Han Chinese Population. Int J Med Sci 2013; 10(11):1584-1588. doi:10.7150/ijms.6360. Available from