International Journal of Medical Sciences

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16 December 2017

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Int J Med Sci 2013; 10(11):1524-1529. doi:10.7150/ijms.6376

Research Paper

The -159C/T Polymorphism in the CD14 Gene and Tuberculosis Risk: A Meta-Analysis

Tao Wang*, Yongchun Shen*, Lei Chen*, Shujin Guo, Liuqun Jia, Ting Yang, Jing An, Fuqiang Wen

Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China and Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, Chengdu 610041, China.
* These authors are equal contributors and co-first authors to this paper.

Abstract

Background: The -159C/T polymorphism in the CD14 gene has been implicated in susceptibility to tuberculosis, but the results were inconclusive. The present meta-analysis aimed to perform a comprehensive assessment of the literature on the possible association between the -159C/T polymorphism and tuberculosis risk.

Methods: We searched in Pubmed and Embase for studies evaluating the association between the -159C/T gene polymorphism and tuberculosis risk. Data were extracted and statistical analysis was performed using Revman 5.1 and STATA 12.0 software.

Results: A total of seven case-control studies involving 3253 subjects (1,574 tuberculosis cases and 1,679 controls) were included. Combined analysis revealed an obvious association between this polymorphism and tuberculosis risk (odds ratio=1.66 and 95% confidence interval: 1.23-2.25, P<0.05 for TT vs. TC+ CC). Sub-group analysis by ethnicity suggested that the risk of tuberculosis associated with the -159C/T polymorphism was significantly elevated among Asians (odds ratio=1.87 and 95% confidence interval: 1.58-2.21, P<0.05 for TT vs. TC+ CC).

Conclusion: This meta-analysis suggests that the -159C/T polymorphism in the CD14 gene contributes to tuberculosis susceptibility. To further investigate gene-gene and gene-environment interactions between this polymorphism and tuberculosis risk, more studies are needed.

Keywords: Tuberculosis, CD14, Polymorphism, Meta-analysis.

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How to cite this article:
Wang T, Shen Y, Chen L, Guo S, Jia L, Yang T, An J, Wen F. The -159C/T Polymorphism in the CD14 Gene and Tuberculosis Risk: A Meta-Analysis. Int J Med Sci 2013; 10(11):1524-1529. doi:10.7150/ijms.6376. Available from http://www.medsci.org/v10p1524.htm