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12 December 2018

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Int J Med Sci 2013; 10(10):1271-1277. doi:10.7150/ijms.6597

Research Paper

Heat Shock Protein27 Expression and Cell Differentiation in Ameloblastomas

Muneteru Fujita1, Keisuke Nakano1,4✉, Akiyoshi Funato2, Yoshihiko Sugita2,5, Katsutoshi Kubo2,5, Hatsuhiko Maeda2,5, Norimasa Okafuji3, Hiromasa Hasegawa1,4, Toshiyuki Kawakami1

1. Hard Tissue Pathology Unit, Matsumoto Dental University Graduate School of Oral Medicine, Shiojiri, Japan;
2. Department of Oral Pathology, School of Dentistry, Aichi Gakuin University, Nagoya, Japan;
3. Clinical Evaluation Unit, Matsumoto Dental University Graduate School of Oral Medicine, Shiojiri, Japan;
4. Department of Oral Pathology, Matsumoto Dental University School of Dentistry, Shiojiri, Japan;
5. Center for Advanced Oral Science, Aichi Gakuin University, Nagoya, Japan.


The expression of HSP27 and some CKs were examined the 40 cases of typical solid/multicystic ameloblastoma using immunohistochemical techniques. In order to examine the relevance of HSP in cell differentiation, we focused on the cytoskeletal expression of CK. CK19 is a marker of typical odontogenic epithelium widely observed in follicular and plexiform types of ameloblastomas. Since staining with CK14 is one of the measures of the differentiation potential of squamous cells and is extensively expressed in both follicular and plexiform types, it implies that squamous differentiation of each type can occur. CK8 was strongly detected in tumor nests in plexiform type but weakly detected in follicular type. It was considered that the expression of HSP27 in plexiform type correlated with the expression of CK8 suggesting that HSP27 might have regulated the expression of CK8.

Keywords: ameloblatoma, immunohistochemistry, HSP, CK, cell differentiation.

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How to cite this article:
Fujita M, Nakano K, Funato A, Sugita Y, Kubo K, Maeda H, Okafuji N, Hasegawa H, Kawakami T. Heat Shock Protein27 Expression and Cell Differentiation in Ameloblastomas. Int J Med Sci 2013; 10(10):1271-1277. doi:10.7150/ijms.6597. Available from