20 March 2018
Int J Med Sci 2013; 10(10):1271-1277. doi:10.7150/ijms.6597
Heat Shock Protein27 Expression and Cell Differentiation in Ameloblastomas
1. Hard Tissue Pathology Unit, Matsumoto Dental University Graduate School of Oral Medicine, Shiojiri, Japan;
The expression of HSP27 and some CKs were examined the 40 cases of typical solid/multicystic ameloblastoma using immunohistochemical techniques. In order to examine the relevance of HSP in cell differentiation, we focused on the cytoskeletal expression of CK. CK19 is a marker of typical odontogenic epithelium widely observed in follicular and plexiform types of ameloblastomas. Since staining with CK14 is one of the measures of the differentiation potential of squamous cells and is extensively expressed in both follicular and plexiform types, it implies that squamous differentiation of each type can occur. CK8 was strongly detected in tumor nests in plexiform type but weakly detected in follicular type. It was considered that the expression of HSP27 in plexiform type correlated with the expression of CK8 suggesting that HSP27 might have regulated the expression of CK8.
Keywords: ameloblatoma, immunohistochemistry, HSP, CK, cell differentiation.
This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.
How to cite this article:
Fujita M, Nakano K, Funato A, Sugita Y, Kubo K, Maeda H, Okafuji N, Hasegawa H, Kawakami T. Heat Shock Protein27 Expression and Cell Differentiation in Ameloblastomas. Int J Med Sci 2013; 10(10):1271-1277. doi:10.7150/ijms.6597. Available from http://www.medsci.org/v10p1271.htm