International Journal of Medical Sciences

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23 January 2019

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Int J Med Sci 2013; 10(9):1224-1230. doi:10.7150/ijms.6640

Research Paper

Which Adverse Events Are Related to Health Care during Hospitalization in Elderly Inpatients?

Julie Dupouy1,2,3,4✉, Guillaume Moulis1,2,4, Marie Tubery1, Marie Ecoiffier1, Agnès Sommet2,4,5, Jean-Christophe Poutrain3, Philippe Arlet1, 3, Maryse Lapeyre-Mestre2,4,5

1. CHU Toulouse, Service de Post-Urgences Médicales/Médecine Interne, place du Docteur Baylac, 31079 Toulouse, Cedex 9, France,
2. UMR 1027 INSERM-Université de Toulouse, Faculté de Médecine, 37 allées Jules Guesde, 31062 Toulouse, France,
3. Département Universitaire de Médecine Générale, 133 route de Narbonne, 31062 Toulouse, France,
4. Université de Toulouse III, 118 route de Narbonne, 31062 Toulouse, Cedex 9, France
5. CHU Toulouse, Service de Pharmacologie Clinique, Centre Midi-Pyrénées de PharmacoVigilance, de Pharmacoépidémiologie et d'Informations sur le Médicament, Faculté de Médecine, 37 allées Jules Guesde, 31000 Toulouse, France


Background: Adverse events result in longer hospital stays and increase costs and mortality. We aimed to assess incidence of adverse events occurring during hospitalization in a post-emergency unit and to describe their characteristics.

Methods: All adverse events occurring in patients during their hospitalization in a post-emergency unit in a French university hospital (20 beds) were systematically and consecutively recorded from September 2009 to February 2011. Patients with adverse events were compared to up to three control patients, matched for date of admission +/- age in the same unit.

Results: We identified 56 patients with 64 adverse events, giving an incidence of 3.0/100 patients admitted/year. Fifty-one adverse events were drug-related. Patients had a median age of 82.5 years with a male/female ratio of 1/1.4. They presented a median Charlson score of 1 and the median number of medications was 6. The drugs most frequently involved in drug-related events were nervous system drugs (47%) and anti-infectives (22%). In multivariate analysis, a Charlson score ≥ 2 was associated with the occurrence of adverse events (OR 0.4; 95% CI [0.21 - 0.80]).

Conclusions: Systematic recording showed that adverse events were not rare in a post-emergency unit. Patients with comorbid conditions were less likely to present an adverse event, possibly because of greater precautions taken by the medical team.

Keywords: Adverse event, inpatients, hospitalization, pharmacovigilance, internal Medicine

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See for full terms and conditions.
How to cite this article:
Dupouy J, Moulis G, Tubery M, Ecoiffier M, Sommet A, Poutrain JC, Arlet P, Lapeyre-Mestre M. Which Adverse Events Are Related to Health Care during Hospitalization in Elderly Inpatients?. Int J Med Sci 2013; 10(9):1224-1230. doi:10.7150/ijms.6640. Available from