Int J Med Sci 2013; 10(8):988-994. doi:10.7150/ijms.5944 This issue Cite

Research Paper

Lack of Association of C-Met-N375S Sequence Variant with Lung Cancer Susceptibility and Prognosis

Jiunn-Min Shieh1,2, Yen-An Tang3, Tsung-Han Yang3, Chih-Yi Chen4, Han-Shui Hsu5, Yi-Hung Carol Tan3, Ravi Salgia6, Yi-Ching Wang3 ✉

1. Department of Chest Medicine, Chi Mei Medical Center, Tainan, Taiwan, R.O.C.;
2. Chang Jung Christian University;
3. Department of Pharmacology and Institute of Basic Medical Science, College of Medicine, National Cheng Kung University, Tainan, Taiwan, R. O. C.;
4. Cancer Center, China Medical University Hospital, Taichung, Taiwan, R. O. C.;
5. Institute of Emergency and Critical Care Medicine, National Yang Ming University, Division of Thoracic Surgery, Taipei Veterans General Hospital, Taiwan, R. O. C.;
6. Departments of Medicine, University of Chicago Medical Center, Chicago, USA.

Citation:
Shieh JM, Tang YA, Yang TH, Chen CY, Hsu HS, Tan YHC, Salgia R, Wang YC. Lack of Association of C-Met-N375S Sequence Variant with Lung Cancer Susceptibility and Prognosis. Int J Med Sci 2013; 10(8):988-994. doi:10.7150/ijms.5944. https://www.medsci.org/v10p0988.htm
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Abstract

Background: Previously, we identified a sequence variant (N375S) of c-Met gene, however, its association with lung cancer risk and prognosis remain undefined.

Patients and Methods: We investigated the genotype distribution of the c-Met-N375S sequence variant in 206 lung cancer patients and 207 non-cancer controls in the Taiwanese population by DNA sequencing.

Results: Lung cancer patients with variant A/G and G/G genotypes showed 1.08-fold increased cancer risk when compared to patients with the wild-type A/A genotype (95% CI, 0.60-1.91). There were no significant differences in postoperative survival between c-Met-N375S and wild-type patients. In the cell model, the c-Met-N375S cells showed a decrease in cell death upon treatment with MET inhibitor SU11274 compared to wild-type cells.

Conclusion: Our data suggest that the c-Met-N375S sequence variant may not play a significant role in cancer susceptibility and the prognosis of lung cancer patients. The correlation with chemoresponse of c-Met-N375S is worth further investigation in patients receiving MET therapy.

Keywords: c-Met, N375S, cancer risk, prognosis, lung cancer.


Citation styles

APA
Shieh, J.M., Tang, Y.A., Yang, T.H., Chen, C.Y., Hsu, H.S., Tan, Y.H.C., Salgia, R., Wang, Y.C. (2013). Lack of Association of C-Met-N375S Sequence Variant with Lung Cancer Susceptibility and Prognosis. International Journal of Medical Sciences, 10(8), 988-994. https://doi.org/10.7150/ijms.5944.

ACS
Shieh, J.M.; Tang, Y.A.; Yang, T.H.; Chen, C.Y.; Hsu, H.S.; Tan, Y.H.C.; Salgia, R.; Wang, Y.C. Lack of Association of C-Met-N375S Sequence Variant with Lung Cancer Susceptibility and Prognosis. Int. J. Med. Sci. 2013, 10 (8), 988-994. DOI: 10.7150/ijms.5944.

NLM
Shieh JM, Tang YA, Yang TH, Chen CY, Hsu HS, Tan YHC, Salgia R, Wang YC. Lack of Association of C-Met-N375S Sequence Variant with Lung Cancer Susceptibility and Prognosis. Int J Med Sci 2013; 10(8):988-994. doi:10.7150/ijms.5944. https://www.medsci.org/v10p0988.htm

CSE
Shieh JM, Tang YA, Yang TH, Chen CY, Hsu HS, Tan YHC, Salgia R, Wang YC. 2013. Lack of Association of C-Met-N375S Sequence Variant with Lung Cancer Susceptibility and Prognosis. Int J Med Sci. 10(8):988-994.

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