International Journal of Medical Sciences

Impact factor
2.399

18 October 2017

ISSN 1449-1907 News feeds of published articles

My Manuscript | My Account

Journal of Genomics now in PubMed/PubMed Central. Submit manuscript...

Journal of Biomedicinenew

Theranostics

Journal of Cancer

Oncomedicine

International Journal of Biological Sciences

Journal of Genomics

Journal of Bone and Joint Infection (JBJI)

Nanotheranostics

PubMed Central Indexed in Journal Impact Factor

Int J Med Sci 2013; 10(5):617-623. doi:10.7150/ijms.5773

Research Paper

The Prognostic Value of Abdominal Aortic Calcification in Peritoneal Dialysis Patients

Hye Eun Yoon1,2, Bo Geun Park1, Hyeon Seok Hwang1, Sungjin Chung1, Cheol Whee Park1, Chul Woo Yang1, Yong-Soo Kim1, Seok Joon Shin1,2✉

1. Department of Internal Medicine, College of Medicine, The Catholic University of Korea;
2. Division of Nephrology, Department of Internal Medicine, Incheon St. Mary's Hospital.

Abstract

Objective: This study evaluated the prognostic value of the aortic calcification index (ACI), an estimate of abdominal aortic calcification by plain abdominal computed tomography (CT), in terms of left ventricular (LV) diastolic dysfunction, mortality, and nonfatal cardiovascular (CV) events in peritoneal dialysis (PD) patients.

Method: PD patients who received both abdominal CT and echocardiography were divided into a low-ACI group (n=46) and a high-ACI group (n=46).

Results: During follow-up (median, 35.2 months; range, 3.6 - 111.3), 30 patients (32.6%) died and 10 patients (10.9%) developed nonfatal cardiovascular (CV) events. The 5-year event-free survival rates for mortality and nonfatal CV events were significantly lower in the high-ACI group compared with those in the low-ACI group (35.7% vs. 64.1%, P = 0.01). The ACI was positively correlated with left atrial diameter and ratio of peak early transmitral flow velocity to peak early diastolic mitral annular velocity (E/E' ratio; a marker of left ventricular diastolic function). Using multivariate analyses, the high-ACI group (vs. low-ACI group, HR 5.25, 95% CI 1.77 - 15.58, P = 0.003) and increased E/E' ratio (HR 1.16, 95% CI 1.03 - 1.31, P = 0.013) were independent predictors for mortality and CV events. The ACI provided a higher predictive value for adverse outcomes (AUC = 0.755, P = 0.002) than the E/E' ratio (AUC = 0.543, P = 0.61).

Conclusion: The ACI was significantly associated with left ventricular diastolic dysfunction and predicted all-cause mortality and nonfatal CV events in PD patients.

Keywords: Aortic calcification, cardiovascular disease, left ventricular diastolic dysfunction, mortality, peritoneal dialysis.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.
How to cite this article:
Yoon HE, Park BG, Hwang HS, Chung S, Park CW, Yang CW, Kim YS, Shin SJ. The Prognostic Value of Abdominal Aortic Calcification in Peritoneal Dialysis Patients. Int J Med Sci 2013; 10(5):617-623. doi:10.7150/ijms.5773. Available from http://www.medsci.org/v10p0617.htm