International Journal of Medical Sciences
ISSN: 1449-1907
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ISSN: 1449-1907
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Int J Med Sci 2013; 10(4):467-474. doi:10.7150/ijms.5607 This issue Cite
Research Paper
Novel Powdered Anti-adhesion Material: Preventing Postoperative Intra-abdominal Adhesions in a Rat Model
1. Division of Surgical Oncology, Department of Translational Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan;
2. Department of Medical Simulation Engineering, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan.
Citation:
Takagi K, Araki M, Fukuoka H, Takeshita H, Hidaka S, Nanashima A, Sawai T, Nagayasu T, Hyon SH, Nakajima N. Novel Powdered Anti-adhesion Material: Preventing Postoperative Intra-abdominal Adhesions in a Rat Model. Int J Med Sci 2013; 10(4):467-474. doi:10.7150/ijms.5607. https://www.medsci.org/v10p0467.htm
Other stylesAbstract
Background: Although laparoscopic surgery has decreased postoperative adhesions, complications induced by adhesions are still of great concern. The aim of this study was to investigate the anti-adhesive effects of a novel powdered anti-adhesion material that can be applied during laparoscopic surgery in comparison with other anti-adhesion materials. Methods: Our novel powdered anti-adhesion material is composed of aldehyde dextran and ε-poly(L-lysine). In 40 male rats, a 2.5×2.0-cm abdominal wall resection and cecum abrasion were performed. The rats were randomized into four groups based on the anti-adhesion treatments: normal saline; Seprafilm®; Interceed®; and novel powdered anti-adhesion material. The animals were euthanized on days 7 and 28 to evaluate the adhesion severity, area of adhesion formation, gross appearance, and pathological changes. Results: The adhesion severities on both days 7 and 28 were significantly lower for all anti-adhesion material groups compared with the normal saline group (p<0.05). Pathologically, all groups showed inflammatory cell infiltration on day 7 and complete regeneration of the peritoneum on day 28. Conclusions: Our novel powdered anti-adhesion material was found to be effective for reducing postoperative intra-abdominal adhesions and showed equivalent efficacy to commercial anti-adhesion materials.
Keywords: adhesion prevention, biodegradable material, powder, anti-adhesion materials, rat model.
Citation styles
APA
Takagi, K., Araki, M., Fukuoka, H., Takeshita, H., Hidaka, S., Nanashima, A., Sawai, T., Nagayasu, T., Hyon, S.H., Nakajima, N. (2013). Novel Powdered Anti-adhesion Material: Preventing Postoperative Intra-abdominal Adhesions in a Rat Model. International Journal of Medical Sciences, 10(4), 467-474. https://doi.org/10.7150/ijms.5607.
ACS
Takagi, K.; Araki, M.; Fukuoka, H.; Takeshita, H.; Hidaka, S.; Nanashima, A.; Sawai, T.; Nagayasu, T.; Hyon, S.H.; Nakajima, N. Novel Powdered Anti-adhesion Material: Preventing Postoperative Intra-abdominal Adhesions in a Rat Model. Int. J. Med. Sci. 2013, 10 (4), 467-474. DOI: 10.7150/ijms.5607.
NLM
Takagi K, Araki M, Fukuoka H, Takeshita H, Hidaka S, Nanashima A, Sawai T, Nagayasu T, Hyon SH, Nakajima N. Novel Powdered Anti-adhesion Material: Preventing Postoperative Intra-abdominal Adhesions in a Rat Model. Int J Med Sci 2013; 10(4):467-474. doi:10.7150/ijms.5607. https://www.medsci.org/v10p0467.htm
CSE
Takagi K, Araki M, Fukuoka H, Takeshita H, Hidaka S, Nanashima A, Sawai T, Nagayasu T, Hyon SH, Nakajima N. 2013. Novel Powdered Anti-adhesion Material: Preventing Postoperative Intra-abdominal Adhesions in a Rat Model. Int J Med Sci. 10(4):467-474.
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