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Int J Med Sci 2012; 9(6):506-512. doi:10.7150/ijms.4787

Research Paper

Mannose Binding Lectin and Macrophage Migration Inhibitory Factor Gene Polymorphisms in Turkish Children with Cardiomyopathy: No Association with MBL2 Codon 54 A/B Genotype, but an Association between MIF -173 CC Genotype

Nilgun Col-Araz1, Sibel Oguzkan-Balci2✉, Osman Baspinar3, Tugce Sever2, Ayse Balat4, Sacide Pehlivan2

1. University of Gaziantep, Faculty of Medicine, Department of Pediatrics, Gaziantep, Turkey.
2. University of Gaziantep, Faculty of Medicine, Department of Medical Biology and Genetics, Gaziantep, Turkey.
3. University of Gaziantep, Faculty of Medicine, Department of Pediatric Cardiology, Gaziantep, Turkey.
4. University of Gaziantep, Faculty of Medicine, Department of Pediatric Nephrology, Gaziantep, Turkey.

Abstract

Myocardial inflammation is one of the commonest mechanisms in cardiomyopathy (CMP). Mannose binding lectin (MBL) is a key molecule in innate immunity, while macrophage migration inhibitory factor (MIF) is a constitutive element of the host defenses. We investigated the possible association between polymorphisms of MBL2 and MIF genes and CMP in Turkish children. Twenty-children with CMP and 30 healthy controls were analyzed for codon 54 A/B polymorphism in MBL, and -173 G/C polymorphism in MIF genes by using PCR-RFLP methods. No significant difference was found between genotypes and alleles of MBL2 gene codon 54 A/B polymorphism in patients and controls (p>0.05). However, serum uric acid levels was found higher in dilated CMP patients with AA genotype. Frequency of MIF -173 CC genotype was significantly higher in patients (p<0.05), and sodium levels were higher in patients with MIF -173 CC genotype. This study is the first to investigate the MBL and MIF gene polymorphisms in Turkish children with CMP. We conclude that CC genotype of MIF (-173) polymorphism may be a risk factor for CMP patients. However, further studies with larger samples are needed to address the exact role of this polymorphism in CMP.

Keywords: Cardiomyopathy, Children, Macrophage migration inhibitory factor, Mannose binding lectin, polymorphism.

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How to cite this article:
Col-Araz N, Oguzkan-Balci S, Baspinar O, Sever T, Balat A, Pehlivan S. Mannose Binding Lectin and Macrophage Migration Inhibitory Factor Gene Polymorphisms in Turkish Children with Cardiomyopathy: No Association with MBL2 Codon 54 A/B Genotype, but an Association between MIF -173 CC Genotype. Int J Med Sci 2012; 9(6):506-512. doi:10.7150/ijms.4787. Available from http://www.medsci.org/v09p0506.htm