International Journal of Medical Sciences

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20 October 2017

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Int J Med Sci 2012; 9(3):200-206. doi:10.7150/ijms.3810

Case Report

Isolated Biliary Cryptococcosis Manifesting as Obstructive Jaundice in an Immunocompetent Adult

Xiujun Cai1, Kun Liu1, Yuelong Liang1, Hong Yu1, Fangfang Lv2, Xiao Liang1✉

1. Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University. China;
2. Department of Infectious Diseases, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University. China.

Abstract

Cryptococcosis is a symptomatic fungal infection caused by Cryptococcus, which frequently occurs in patients who are immunologically compromised or chronically ill. Localized involvement of the hepatobiliary system in an immunocompetent adult is extremely rare. We report a unique case of isolated biliary cryptococcosis manifesting as obstructive jaundice and mimicking hilar cholangiocarcinoma in an immunocompetent woman. By integrating surgical and antifungal drug therapy, the disease was effectively controlled. Despite an increasing incidence of biliary malignancies, hepatobiliary surgeons and gastroenterologists must maintain a high index of suspicion for other rare possibilities of non-specific biliary inflammation.

Keywords: Biliary cryptococcosis, Obstructive jaundice, Cholangiocarcinoma, Cryptococcus neoformans, Itraconazole.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.
How to cite this article:
Cai X, Liu K, Liang Y, Yu H, Lv F, Liang X. Isolated Biliary Cryptococcosis Manifesting as Obstructive Jaundice in an Immunocompetent Adult. Int J Med Sci 2012; 9(3):200-206. doi:10.7150/ijms.3810. Available from http://www.medsci.org/v09p0200.htm