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Int J Med Sci 2011; 8(6):470-478. doi:10.7150/ijms.8.470

Research Paper

The Relationship between Serum Uric Acid and Spirometric Values in Participants in a Health Check: The Takahata Study

Yasuko Aida1, Yoko Shibata1✉, Daisuke Osaka1, Shuichi Abe1, Sumito Inoue1, Koji Fukuzaki1, Yoshikane Tokairin1, Akira Igarashi1, Keiko Yamauchi1, Takako Nemoto1, Keiko Nunomiya1, Hiroyuki Kishi1, Masamichi Sato1, Tetsu Watanabe1, Tsuneo Konta1, Sumio Kawata2, Takeo Kato3, Isao Kubota1

1. Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan
2. Department of Gastroenterology, Yamagata University Hospital, Yamagata, Japan
3. Department of Neurology, Hematology, Metabolism, Endocrinology, and Diabetology, Yamagata University School of Medicine, Yamagata, Japan

Abstract

Background: Tissue hypoxia induces the degradation of adenosine triphosphate, resulting in the production of uric acid (UA). Patients with chronic obstructive pulmonary disease (COPD) have been reported to have high serum levels of UA (sUA), compared with control subjects. However, the relationship between sUA levels and spirometric measures has not been investigated in detail in a general population.

Methods: Subjects aged 40 years or older (n = 2,917), who had participated in a community-based annual health check in Takahata, Japan, in 2004 and 2005, were enrolled in the study. These subjects performed spirometry, their blood pressure was measured, and a blood sample was taken.

Results: sUA levels were significantly higher in males than in females. Percent predicted forced vital capacity [FVC %predicted] (r = -0.13) and forced expiratory volume in 1 s [FEV1 %predicted] (r = -0.118) were inversely correlated with sUA levels in females but not in males. Univariate regression analysis indicated that age, body mass index (BMI), ethanol intake, mean blood pressure (BP), and serum creatinine (sCr) were significantly associated with sUA levels in males. In females, age, BMI, mean BP, hemoglobin A1c, sCr, FVC %predicted, and FEV1 %predicted were significantly associated with sUA levels. Multiple linear regression analysis showed that for both genders, FVC %predicted and FEV1 %predicted were predictive for sUA levels, independently of the other clinical parameters. Subjects with lung restriction had higher sUA levels than subjects without lung restriction. In addition, subjects with moderate and severe airflow limitation had higher sUA levels than subjects without airflow limitation or those with mild airflow limitation.

Conclusion: FVC %predicted and FEV1 %predicted were significantly associated with sUA levels in a general population.

Keywords: uric acid, spirometry, pulmonary function, epidemiology

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.
How to cite this article:
Aida Y, Shibata Y, Osaka D, Abe S, Inoue S, Fukuzaki K, Tokairin Y, Igarashi A, Yamauchi K, Nemoto T, Nunomiya K, Kishi H, Sato M, Watanabe T, Konta T, Kawata S, Kato T, Kubota I. The Relationship between Serum Uric Acid and Spirometric Values in Participants in a Health Check: The Takahata Study. Int J Med Sci 2011; 8(6):470-478. doi:10.7150/ijms.8.470. Available from http://www.medsci.org/v08p0470.htm