23 October 2018
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Int J Med Sci 2011; 8(5):380-386. doi:10.7150/ijms.8.380
Prevention of Pleural Adhesions Using a Membrane Containing Polyethylene Glycol in Rats
1. Department of Thoracic Surgery, State Hospital, Bilecik, Turkey
Background: Recurrent thoracotomies regardless of the cause are not a rare occurrence. However, each thoracotomy results in adhesion to some extent. This adhesions increase morbidity and mortality presents a significant inconvenience for surgeons and prolongs the length of operations.
Objective: We investigated the efficacy of Prevadh®, an anti-adhesion agent to prevent intrapleural adesions following thoracotomy in a rat model.
Methods: Twenty male adult Wistar Albino rats were divided into a sham group (Group A, n = 4), a control group (Group B, n = 8), and a study group (Group C, n = 8). Only left thoracotomy was performed in Group A. Group B underwent left thoracotomy, induction of adhesion, and 1 ml saline solution was administered to the thoracic cavity. However, in Group C underwent left thoracotomy, induction of adhesion, and Prevadh® was placed between the pleura and the lung. The rats were sacrificed on day 21, and adhesions were analyzed using both macroscopic and histopathological methods. The results were statistically analyzed. A value of P<0.05 was considered statistically significant.
Results: Mean lengths of adhesion differed statistically significantly among all three groups, while mean intensity of adhesion differed between Group A and Group B, and between Group B and Group C (P>0.05). There was also a statistically significant difference between Group A and Group C in mesothelium proliferation score (P>0.05). No statistically significant differences were found among the groups in terms of pleural thickness, macrophage and mononuclear cell infiltration (P>0.05).
Conclusions: Prevadh® was shown in a rat model to effectively prevent post-thoracotomy adhesions.
Keywords: Thoracic Surgery, Thoracotomy, Tissue Adhesions, Polyethylene Glycols
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How to cite this article:
Karacam V, Onen A, Sanli A, Gurel D, Kargi A, Karapolat S, Ozdemir N. Prevention of Pleural Adhesions Using a Membrane Containing Polyethylene Glycol in Rats. Int J Med Sci 2011; 8(5):380-386. doi:10.7150/ijms.8.380. Available from http://www.medsci.org/v08p0380.htm