International Journal of Medical Sciences

Impact factor

16 December 2018

ISSN 1449-1907 News feeds of published articles

Manuscript login | Account

open access Global reach, higher impact

Journal of Genomics in PubMed Central. Submit manuscript now...


Journal of Cancer

International Journal of Biological Sciences

Journal of Genomics



Journal of Biomedicine

PubMed Central Indexed in Journal Impact Factor

Int J Med Sci 2011; 8(3):254-262. doi:10.7150/ijms.8.254

Research Paper

Prevalence and Etiology of Abnormal Liver Tests in an Adult Population in Jilin, China

Hong Zhang, Shu Mei He, Jie Sun, ChunYan Wang, Yan Fang Jiang, Qing Gu, Xiang Wei Feng, Bing Du, Wei Wang, Xiao Dong Shi, Si Qi Zhang, Wan Yu Li, Jun Qi Niu

Department of Hepatology, First Hospital, Jilin University, Changchun 130021, China


Background: Serum biochemical liver tests (LTs) (alanine aminotransferase, aspartate aminotransferase, and gamma glutamyltransferase) and platelet counts are often used to screen for chronic liver disease. We determined the prevalence and etiologies of abnormal LTs in an adult population in Jilin, China.

Methods: A total of 3791 individuals between the ages of 18 and 79 years were interviewed and then underwent ultrasonography and blood tests.

Results: The prevalence of abnormal LTs was 14.77% (560 out of 3791 subjects). The risk factors for abnormal LTs were non-alcoholic fatty liver disease (NAFLD) alone, which accounted for 11.61%, metabolic syndrome alone for 25%, or both for 22.14%. Abnormal LTs were more common in male than in female subjects. The development of abnormal LTs was correlated with older age males, increased daily alcohol intake, poor quality of sleep, smoking, fasting plasma glucose, body mass index, triglyceridemia, and low-density lipoprotein. Abnormal LTs in patients with metabolic syndrome and NAFLD were associated with high fasting plasma glucose, triglycerides, body mass index, low density lipoprotein, male, young age, poor sleep quality, smoking, and alcohol intake. However, abnormal LTs in patients with hepatitis B virus were associated with gender and increased age.

Conclusions: The results from the current study demonstrated that the prevalence of abnormal LTs is high in the population (14.77%). Metabolic syndrome, NAFLD, and alcohol intake appear to be potentially important causes of the observed abnormal LTs.

Keywords: alanine aminotransferase, metabolic syndrome, non-alcoholic fatty liver disease, ultrasonography, seroepidemiologic marker.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See for full terms and conditions.
How to cite this article:
Zhang H, He SM, Sun J, Wang C, Jiang YF, Gu Q, Feng XW, Du B, Wang W, Shi XD, Zhang SQ, Li WY, Niu JQ. Prevalence and Etiology of Abnormal Liver Tests in an Adult Population in Jilin, China. Int J Med Sci 2011; 8(3):254-262. doi:10.7150/ijms.8.254. Available from