International Journal of Medical Sciences

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23 October 2017

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Int J Med Sci 2010; 7(3):136-146. doi:10.7150/ijms.7.136

Research Paper

Gain of a 500-fold sensitivity on an intravital MR Contrast Agent based on an endohedral Gadolinium-Cluster-Fullerene-Conjugate: A new chance in cancer diagnostics

Klaus Braun1 , Lothar Dunsch2, Ruediger Pipkorn3, Michael Bock1, Tobias Baeuerle1, Shangfeng Yang2,4, Waldemar Waldeck5, Manfred Wiessler1

1. Department of Medical Physics in Radiology, German Cancer Research Center, INF 280, D-69120 Heidelberg, Germany
2. Department of Electrochemistry and conducting Polymers; Leibniz-Institute for Solid State and Materials Research, Helmholtzstraße 20, D-01069 Dresden, Germany
3. Core Facility Peptide Synthesis, German Cancer Research Center, INF 580, D-69120 Heidelberg, Germany
4. Hefei National Laboratory for Physical Sciences at Microscale &Department of Materials Science and Engineering, Hefei 230026, China
5. Biophysics of Macromolecules, German Cancer Research Center, INF 580, D-69120, Heidelberg, Germany

Abstract

Among the applications of fullerene technology in health sciences the expanding field of magnetic resonance imaging (MRI) of molecular processes is most challenging. Here we present the synthesis and application of a GdxSc3-xN@C80-BioShuttle-conjugate referred to as Gd-cluster@-BioShuttle, which features high proton relaxation and, in comparison to the commonly used contrast agents, high signal enhancement at very low Gd concentrations. This modularly designed contrast agent represents a new tool for improved monitoring and evaluation of interventions at the gene transcription level. Also, a widespread monitoring to track individual cells is possible, as well as sensing of microenvironments. Furthermore, BioShuttle can also deliver constructs for transfection or active pharmaceutical ingredients, and scaffolding for incorporation with the host's body. Using the Gd-cluster@-BioShuttle as MRI contrast agent allows an improved evaluation of radio- or chemotherapy treated tissues.

Keywords: inverse Diels Alder Reaction, BioShuttle, fullerenes, gadolinium, intravital Imaging, nitridecluster fullerenes, intracellular imaging, Magnetic Resonance Imaging (MRI), metallofullerenes, Molecular Imaging, Rare Earth compounds

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How to cite this article:
Braun K, Dunsch L, Pipkorn R, Bock M, Baeuerle T, Yang S, Waldeck W, Wiessler M. Gain of a 500-fold sensitivity on an intravital MR Contrast Agent based on an endohedral Gadolinium-Cluster-Fullerene-Conjugate: A new chance in cancer diagnostics. Int J Med Sci 2010; 7(3):136-146. doi:10.7150/ijms.7.136. Available from http://www.medsci.org/v07p0136.htm