International Journal of Medical Sciences

Impact factor

16 January 2019

ISSN 1449-1907 News feeds of published articles

Manuscript login | Account

open access Global reach, higher impact

Journal of Genomics in PubMed Central. Submit manuscript now...


Journal of Cancer

International Journal of Biological Sciences

Journal of Genomics



Journal of Biomedicine

PubMed Central Indexed in Journal Impact Factor

Int J Med Sci 2008; 5(5):240-243. doi:10.7150/ijms.5.240

Short Research Communication

IGF-1 regulates cAMP levels in astrocytes through a β2-adrenergic receptor-dependant mechanism

Daniel Chesik, Nadine Wilczak, Jacques De Keyser

Department of Neurology, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, the Netherlands


We have recently demonstrated that neonatal astrocytes derived from mice lacking beta-2 adrenergic receptors (β2AR) possess higher proliferation rates, as compared to wild-type cells, an attribute that was shown to involve insulin-like growth factor (IGF) signaling. In the present study, we demonstrate that basal cAMP levels in β2AR knockout astrocytes were significantly lower than in wild type cells. Furthermore, treatment with IGF-1 reduced intracellular cAMP levels in wild type astrocytes, yet had no effects on cAMP levels in β2AR deficient astrocytes. Our data suggests that IGF-1 treatment influences cAMP production through a β2AR-dependant mechanism in astrocytes. A deficit of β2AR on astrocytes, as previously reported in multiple sclerosis, may influence cell proliferation, an action which could have implications in processes involved in astrogliosis.

Keywords: beta adrenergic receptors, insulin-like growth factor, cyclic adenosine monophosphate, astrocytes, multiple sclerosis

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See for full terms and conditions.
How to cite this article:
Chesik D, Wilczak N, De Keyser J. IGF-1 regulates cAMP levels in astrocytes through a β2-adrenergic receptor-dependant mechanism. Int J Med Sci 2008; 5(5):240-243. doi:10.7150/ijms.5.240. Available from