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Int J Med Sci 2008; 5(4):224-229. doi:10.7150/ijms.5.224

Research Paper

Significant association between Helicobacter pylori infection and serum C-reactive protein

Yoshiko Ishida1, Koji Suzuki2, Kentaro Taki3, Toshimitsu Niwa3, Shozo Kurotsuchi4, Hisao Ando5, Akira Iwase6, Kazuko Nishio1, Kenji Wakai1, Yoshinori Ito1, Nobuyuki Hamajima1

1. Department of Preventive Medicine/Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Nagoya, Japan
2. Department of Public Health, Fujita Health University School of Health Sciences
3. Department of Clinical Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan
4. Department of Obstetrics and Gynecology, Toyota Kosei Hospital, Toyota, Japan
5. Center for Reproductive Medicine, Toyohashi Municipal Hospital, Toyohashi, Japan.
6. Department of Obstetrics and Gynecology and Department of Maternal and Perinatal Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.


Background: Helicobacter pylori (H. pylori) infection in gastric mucosa may cause systemic inflammatory reaction. This study aimed to examine the association between the infection and serum high sensitivity C-reactive protein (hsCRP).

Methods: Subjects were comprised of three groups; 453 health checkup examinees from Yakumo town inhabitants in Hokkaido, Japan (YTI, 153 males and 300 females), 449 health checkup examinees (ENUH, 273 males and 176 females), and 255 female patients of an infertility clinic (PIC), Nagoya University Hospital. Twenty participants with hsCRP more than 1 mg/dl were excluded from the analysis. Those with hsCRP more than 0.1mg/dl were defined as high hsCRP individuals. H. pylori infection status was examined with a serum IgG antibody test.

Results: When the three groups were combined, the geometric mean of hsCRP concentration was significantly higher among the seropositives (0.047mg/dl) than among the seronegatives (0.035mg/dl); p<0.0001 by a t-test. The percentage of high hsCRP individuals was also higher in the seropositives than in the seronegatives among any group; 23.3% and 20.1% in YTI, 22.0% and 16.0% in ENUH, and 32.7% and 18.7% in PIC, respectively, although the difference was significant only in ENUH. The summary odds ratio of the high hsCRP for the seropositives relative to the seronegatives was 1.38 (95% confidence interval, 1.01-1.89), when age, sex, body mass index, smoking, and subject group were adjusted by a logistic model.

Conclusions: In three groups, hsCRP was higher among the infected individuals. The summary odd ratio indicated that H. pylori infection could influence the serum hsCRP level.

Keywords: C-reactive protein, Helicobacter pylori infection, inflammation, serum antibody, smoking

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See for full terms and conditions.
How to cite this article:
Ishida Y, Suzuki K, Taki K, Niwa T, Kurotsuchi S, Ando H, Iwase A, Nishio K, Wakai K, Ito Y, Hamajima N. Significant association between Helicobacter pylori infection and serum C-reactive protein. Int J Med Sci 2008; 5(4):224-229. doi:10.7150/ijms.5.224. Available from