9 February 2012

ISSN 1449-1907

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International Journal of Biological Sciences

Journal of Cancer

Theranostics

Journal of Genomics

Int J Med Sci 2007; 4(5):264-266. doi:10.7150/ijms.4.264

Research Paper

Immunohistochemical Characteristics of Bone Forming Cells in Pleomorphic Adenoma

Keisuke Nakano^{1, 2}, Takehiro Watanabe¹, Takako Shimizu², Toshiyuki Kawakami ^{1, 2}

1. Hard Tissue Pathology Unit, Matsumoto Dental University Graduate School of Oral Medicine, Shiojiri, Japan
2. Hard Tissue Pathology Unit, Matsumoto Dental University Institute for Oral Science, Shiojiri, Japan

Abstract

Histopathological and immunohistochemical examinations were carried out in a case of pleomorphic adenoma with bone formation, occurring in the chin of a 34-year-old Japanese man. Examination results showed the modified neoplastic myoepithelial cells reacted positively to S-100 protein. The S-100-positive modified neoplastic myoepithelial cells were proliferated in the closely related area of the bone tissue. Furthermore, positive reaction was detected in the bone forming cells: osteoblasts and osteocytes. These cells also reacted positively to Runx2 as a marker of bone forming cells. These results suggest that the origin of the bone forming cells in this case of pleomorphic adenoma was modified neoplastic myoepithelial cells.

Keywords: Bone forming cells, Immunohistochemical characteristics, Pleomorphic adenoma, Modified myoepithelial cell, Trans-differentiation