International Journal of Medical Sciences

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19 October 2017

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Int J Med Sci 2007; 4(5):242-246. doi:10.7150/ijms.4.242

Research Paper

Do tonic and burst TMS modulate the lemniscal and extralemniscal system differentially?

Dirk De Ridder 1, Elsa van der Loo 1, Karolien Van der Kelen 1, Tomas Menovsky 1, Paul van de Heyning 1, Aage Moller 2

1. Dept of Neurosurgery and ENT, University Hospital Antwerp, Belgium
2. School of Behavioral and Brain Science, University of Texas at Dallas, Dallas, USA

Abstract

Introduction: Tinnitus is an auditory phantom percept related to tonic and burst hyperactivity of the auditory system. Two parallel pathways supply auditory information to the cerebral cortex: the tonotopically organised lemniscal system, and the non-tonotopic extralemniscal system, firing in tonic mode and burst mode respectively. Transcranial magnetic stimulation (TMS) is a non-invasive method capable of modulating activity of the human cortex, by delivering tonic or burst stimuli. Burst stimulation is shown to be more powerful in activating the cerebral cortex than tonic stimulation and bursts may activate neurons that are not activated by tonic stimulations.

Methods: The effect of both tonic and burst TMS in 14 placebo-negative patients presenting narrow band/white noise tinnitus were analysed.

Results: Our TMS results show that narrow band/white noise tinnitus is better suppressed with burst TMS in comparison to tonic TMS, t(13)=6.4, p=.000. For pure tone tinnitus no difference is found between burst or tonic TMS, t(13)=.3, ns.

Discussion: Based on the hypothesis that white noise is the result of hyperactivity in the non-tonotopic system and pure tone tinnitus of the tonotopic system, we suggest that burst stimulation modulates the extralemniscal system and lemniscal system and tonic stimulation only the lemniscal system.

Keywords: Burst, extralemniscal, lemniscal, TMS, Tonic

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.
How to cite this article:
De Ridder D, van der Loo E, Van der Kelen K, Menovsky T, van de Heyning P, Moller A. Do tonic and burst TMS modulate the lemniscal and extralemniscal system differentially?. Int J Med Sci 2007; 4(5):242-246. doi:10.7150/ijms.4.242. Available from http://www.medsci.org/v04p0242.htm