21 June 2018
Int J Med Sci 2007; 4(4):203-208. doi:10.7150/ijms.4.203
In vivo bactericidal activities of Japanese rice-fluid against H. pylori in a Mongolian gerbil model
1. Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan
Purpose: The antibiotic effect of rice-fluid on Helicobacter pylori infection was investigated using a Mongolian gerbil model.
Methods: Gerbils were divided into four groups: H. pylori -infected, rice-fluid-treated animals (group A); H. pylori -infected, untreated animals (group B); uninfected, rice-fluid-treated animals (group C); and uninfected, untreated animals (group D). Group A and B animals were killed 14 weeks after H. pylori infection and group C and D animals were killed at the same age. The stomachs were examined for histology, 5'-bromo-2'-deoxyuridine (BrdU) labeling, and the bacterial burden. Serum anti-H. pylori antibody titers were also tested.
Results: The positive incidence of H. pylori -culture was 25 and 84 % in groups A and B, respectively (p<0.01). Both the degree of inflammation and the BrdU labeling index in group A were significantly lower than those in group B.
Conclusions: Rice-fluid showed an antibiotic effect on H. pylori and an anti-inflammatory effect on the H. pylori -associated gastritis.
Keywords: Japanese Rice-fluid, Helicobacter pylori, Mongolian gerbil, eradication, prevention
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How to cite this article:
Ishizone S, Maruta F, Suzuki K, Miyagawa S, Takeuchi M, Kanaya K, Oana K, Hayama M, Kawakami Y, Ota H. In vivo bactericidal activities of Japanese rice-fluid against H. pylori in a Mongolian gerbil model. Int J Med Sci 2007; 4(4):203-208. doi:10.7150/ijms.4.203. Available from http://www.medsci.org/v04p0203.htm