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13 December 2018

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Int J Med Sci 2007; 4(4):203-208. doi:10.7150/ijms.4.203

Research Paper

In vivo bactericidal activities of Japanese rice-fluid against H. pylori in a Mongolian gerbil model

Satoshi Ishizone1, Fukuto Maruta1, Kazufumi Suzuki1, Shinichi Miyagawa1, Masahiko Takeuchi2, Kiyomi Kanaya3, Kozue Oana4, Masayoshi Hayama4, Yoshiyuki Kawakami4, Hiroyoshi Ota4

1. Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan
2. Agricultural Technology Institute, Nagano Farmer's Federation, Japan
3. Nagano Kohno, Co., Ltd., Japan
4. Department of Biomedical Laboratory Sciences, School of Health Sciences, Shinshu University School of Medicine, Japan


Purpose: The antibiotic effect of rice-fluid on Helicobacter pylori infection was investigated using a Mongolian gerbil model.

Methods: Gerbils were divided into four groups: H. pylori -infected, rice-fluid-treated animals (group A); H. pylori -infected, untreated animals (group B); uninfected, rice-fluid-treated animals (group C); and uninfected, untreated animals (group D). Group A and B animals were killed 14 weeks after H. pylori infection and group C and D animals were killed at the same age. The stomachs were examined for histology, 5'-bromo-2'-deoxyuridine (BrdU) labeling, and the bacterial burden. Serum anti-H. pylori antibody titers were also tested.

Results: The positive incidence of H. pylori -culture was 25 and 84 % in groups A and B, respectively (p<0.01). Both the degree of inflammation and the BrdU labeling index in group A were significantly lower than those in group B.

Conclusions: Rice-fluid showed an antibiotic effect on H. pylori and an anti-inflammatory effect on the H. pylori -associated gastritis.

Keywords: Japanese Rice-fluid, Helicobacter pylori, Mongolian gerbil, eradication, prevention

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See for full terms and conditions.
How to cite this article:
Ishizone S, Maruta F, Suzuki K, Miyagawa S, Takeuchi M, Kanaya K, Oana K, Hayama M, Kawakami Y, Ota H. In vivo bactericidal activities of Japanese rice-fluid against H. pylori in a Mongolian gerbil model. Int J Med Sci 2007; 4(4):203-208. doi:10.7150/ijms.4.203. Available from