International Journal of Medical Sciences

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25 March 2018

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Int J Med Sci 2006; 3(2):79-83. doi:10.7150/ijms.3.79


Management of HCV Infection and Liver Transplantation

Thomas D. Schiano, Paul Martin

Adult Liver Transplantation, Recanati/Miller Transplantation Institute, Division of Liver Diseases, Department of Medicine, The Mount Sinai School of Medicine, New York, NY, USA


A major challenge facing liver transplant recipients and their physicians is recurrence of hepatitis C virus infection following otherwise technically successful liver transplantation. Recurrent infection leads to diminished graft and patient survival. Although a number or predictors of severe recurrence have been identified, no definitive strategy has been developed to prevent recurrence. Generally the tempo of hepatitis C recurrence is gauged by serial liver biopsies with the decision to intervene with antiviral therapy based on local philosophy and expertise. Treating hepatitis C in this population has a number of major challenges including diminished patient tolerance for side-effects as well as managing the patient's immunesuppression. However sustained viral responses are possible with the potential to reduce the impact of recurrent hepatitis on the graft. However recurrent hepatitis C virus infection will remain the most frequent form of recurrent disease in liver transplant programs for the foreseeable future.

Keywords: recurrent hepatitis C, liver transplantation, antiviral therapy

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See for full terms and conditions.
How to cite this article:
Schiano TD, Martin P. Management of HCV Infection and Liver Transplantation. Int J Med Sci 2006; 3(2):79-83. doi:10.7150/ijms.3.79. Available from