International Journal of Medical Sciences

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Int J Med Sci 2006; 3(2):63-68. doi:10.7150/ijms.3.63

Review

A Practical Approach to Managing Patients with HCV Infection

Richard H. Huang, Ke-Qin Hu

Division of Gastroenterology and Hepatology, University of California, Irvine Medical Center, CA 92868, USA

Abstract

Hepatitis C virus (HCV) infection is a major worldwide public health concern. It is a common cause of chronic liver disease and hepatocellular carcinoma. HCV antibody and HCV RNA testing are available diagnostic studies that offer high degree of accuracy. Current standard therapy includes a combination of pegylated interferon and ribavirin. Response rate is approximately 40% for genotype 1 and 80% for genotypes 2 and 3, respectively. Successful treatment can stop the progression of chronic liver disease, reduce the need for liver transplantation, and possibly decrease the risk for Hepatocellular carcinoma (HCC). Evaluating for potential treatment candidacy is an important initial step in the management of chronic HCV infection as not all individuals may need or qualify for the treatment. Understanding the natural history, the different diagnostic modalities, the current therapeutic options and, the treatment response and adverse effect profiles can help the practitioners better manage chronic HCV infection.

Keywords: Chronic Hepatitis C, treatment, interferon, PEG-interferon, ribavirin

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.
How to cite this article:
Huang RH, Hu KQ. A Practical Approach to Managing Patients with HCV Infection. Int J Med Sci 2006; 3(2):63-68. doi:10.7150/ijms.3.63. Available from http://www.medsci.org/v03p0063.htm