11 February 2012
ISSN 1449-1907 
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11 February 2012 ISSN 1449-1907 |
International Journal of Biological Sciences 
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Int J Med Sci 2006; 3(2):29-34. doi:10.7150/ijms.3.29 Review Molecular Virology of Hepatitis C Virus (HCV): 2006 Update 1. Department of Medicine II, University of Freiburg, D-79106 Freiburg, Germany Fascinating progress in the understanding of the molecular biology of hepatitis C virus (HCV) was achieved recently. The replicon system revolutionized the investigation of HCV RNA replication and facilitated drug discovery. Novel systems for functional analyses of the HCV glycoproteins allowed the validation of HCV receptor candidates and the investigation of cell entry mechanisms. Most recently, recombinant infectious HCV could be produced in cell culture, rendering all steps of the viral life cycle, including entry and release of viral particles, amenable to systematic analysis. In this review, we summarize recent advances and discuss future research directions. Keywords: helicase, hepatitis C virus, protease, polymerase, replicon How
to cite this article:
Brass V, Moradpour D, Blum HE. Molecular Virology of Hepatitis C Virus (HCV): 2006 Update. Int J Med Sci 2006; 3(2):29-34. Available from http://www.medsci.org/v03p0029.htm |