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International Journal of Biological Sciences

Int J Med Sci 2006; 3:26-27 ©Ivyspring International Publisher

Case Report

Hb J- Meerut [α 120 (H3) Ala ->Glu (α1)] In A Turkish Male

Gunçag Dinçol¹, Serkan Güvenç¹, Dedrey Elam², Abdullah Kutlar², Ferdane Kutlar²

1. Division of Hematology, Department of Internal Medicine, Istanbul Medical School, University of Istanbul, Çapa, Istanbul, Turkey
2. Titus H.J. Huisman Hemoglobinopathy Laboratory, Department of Medicine, Medical College of Georgia, Augusta, Georgia, USA

Abstract

Hb J Meerut is an infrequently found α-globin variant. It has previously been reported in various populations around the world. One particular case reported in 1994 included a Turkish family. In this report, details of a second case of Hb J Meerut in a Turkish male who is unrelated to the first family are described. In the present case a slight increase in the oxygen affinity of Hb J Meerut, relative to that of the normal control, has been observed as detected by low p50 values in arterial whole blood. Additionally, a slight increase in red blood cell count, as compared against a normal individual, was observed.

Keywords: Hb J-Meerut [α 120 (H3) Ala->Glu (α1)], DNA analysis, Turkish male, slightly increased oxygen affinity