International Journal of Medical Sciences

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23 October 2017

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Int J Med Sci 2005; 2(1):17-23. doi:10.7150/ijms.2.17

Review

A Practical Approach to Management of Chronic Hepatitis B

Ke-Qin Hu

Divisions of Gastroenterology and Transplantation, University of California, Irvine, College of Medicine, CA, USA

Abstract

Chronic hepatitis B (CHB) is one of the important public health problems worldwide. Major advances have been made in the treatment of CHB during the past several years. This article systemically reviews advances in the application of HBV DNA quantitation and three approved drugs for HBV treatment, and presents an updated and practical clinical approach to managing CHB. Highly sensitive PCR-based quantitation of HBV DNA makes it possible to precisely determine pre-treatment HBV load and monitor HBV DNA response during treatment. HBV DNA level, HBeAg status, degree of hepatic histological activity and fibrosis, and serum transaminases are the most important parameters in determining indication, regimen, and duration of HBV treatment. Although interferon alfa-2b, lamivudine, and adefovir are all approved as initial HBV treatment, understanding the advantages and advantages of each agent is important in choosing the best treatment for each individual patient with CHB.

Keywords: Chronic Hepatitis B, Management, treatment

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.
How to cite this article:
Hu KQ. A Practical Approach to Management of Chronic Hepatitis B. Int J Med Sci 2005; 2(1):17-23. doi:10.7150/ijms.2.17. Available from http://www.medsci.org/v02p0017.htm