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Int J Med Sci 2024; 21(8):1428-1437. doi:10.7150/ijms.96414 This issue Cite

Research Paper

Impact of CD44 genetic variants on clinicopathological characteristics of uterine cervical cancer patients

Yi-Hung Sun^1,2,3,4,#, Ching-Ming Wang^5,#, Huang-Pin Shen^3,6,7, Chung-Yuan Lee^8,9, Chiao-Wen Lin¹⁰, Shun-Fa Yang^3,11, Po-Hui Wang^3,6,7,✉

1. Department of Obstetrics and Gynecology, Chi-Mei Foundation Medical Center, Tainan, Taiwan.
2. School of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
3. Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
4. School of Medicine, National Defense Medical Center, Taipei, Taiwan.
5. School of Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
6. School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
7. Department of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung, Taiwan.
8. Department of Obstetrics and Gynecology, Chiayi Chang Gung Memorial Hospital Chiayi, Taiwan.
9. Department of Nursing, Chang Gung University of Science and Technology, Chiayi Campus, Chiayi, Taiwan.
10. Institute of Oral Sciences, Chung Shan Medical University, Taichung, Taiwan.
11. Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan.
^#Equal contribution as first authors.

✉ Corresponding author: Po-Hui Wang, MD, PhD, Institute of Medicine, Chung Shan Medical University, 110, Section 1, Chien-Kuo North Road, Taichung, 40201, Taiwan. Tel.: 886-4-24739595 ext. 21721; Fax: 884-4-24738493; E-mail: wang082160com.

Abstract

CD44 genetic variants have been found to be related to various cancers. However, to date, no study has demonstrated the involvement of CD44 polymorphisms in uterine cervical cancer in Taiwanese women. Therefore, we conducted a retrospective study, consecutively recruiting 113 patients with invasive cancer, 92 patients with high-grade cervical intraepithelial neoplasias, and 302 control women to assess the relationships among CD44 polymorphisms, cervical carcinogenesis, and patient survival. Real-time polymerase chain reaction was used to determine the genotypic distributions of six polymorphisms: rs1425802, rs187115, rs713330, rs11821102, rs10836347, and rs13347. The results revealed that women with the mutant homozygous genotype CC exhibited a higher risk of invasive cancer compared to those with the wild homozygous genotype TT [p=0.035; hazard ratio (HR)=10.29, 95% confidence interval (95% CI)=1.18-89.40] and TT/TC [p=0.032; HR=10.66, 95% CI=1.23-92.11] in the CD44 polymorphism rs713330. No significant association was found between CD44 genetic variants and clinicopathological parameters. Among the clinicopathological parameters, only positive pelvic lymph node metastasis (p=0.002; HR=8.57, 95% CI=2.14-34.38) and the AG/GG genotype compared to AA (p=0.014; HR=3.30, 95% CI=1.28-8.49) in CD44 polymorphism rs187115 predicted a higher risk of poor five-year survival, according to multivariate analysis. In conclusion, an important and novel finding revealed that Taiwanese women with the AG/GG genotype in CD44 polymorphism rs187115 exhibited a higher risk of poor five-year survival.

Keywords: CD44, genetic variants, rs187115, cancer of uterine cervix, 5 years survival rate

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