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Int J Med Sci 2024; 21(7):1307-1320. doi:10.7150/ijms.96274 This issue Cite

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Cross-Talk between the TGF-β and Cell Adhesion Signaling Pathways in Cancer

Jiahao Liao1,2†, Rentang Chen1,2†, Bihua Lin1†, Runhua Deng1, Yanfang Liang3, Jincheng Zeng1✉, Sha Ma4✉, Xianxiu Qiu1✉

1. Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan Key Laboratory of Medical Bioactive Molecular Developmental and Translational Research, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, Guangdong, 523808, China.
2. Institute of Laboratory Medicine, School of Medical Technology, Guangdong Medical University, Dongguan, Guangdong, 523808, China.
3. Department of Pathology, Binhaiwan Central Hospital of Dongguan, Dongguan, Guangdong, 523905, China.
4. School of Biomedical Engineering, Guangdong Medical University, Dongguan, Guangdong, 523808, China.
† These authors have contributed equally to this work.

✉ Corresponding authors: Xianxiu Qiu: bmsqiuedu.cn; Sha Ma: smaedu.cn; Jincheng Zeng: zengjcedu.cn.

Citation:
Liao J, Chen R, Lin B, Deng R, Liang Y, Zeng J, Ma S, Qiu X. Cross-Talk between the TGF-β and Cell Adhesion Signaling Pathways in Cancer. Int J Med Sci 2024; 21(7):1307-1320. doi:10.7150/ijms.96274. https://www.medsci.org/v21p1307.htm
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Abstract

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Transforming growth factor-β (TGF-β) is strongly associated with the cell adhesion signaling pathway in cell differentiation, migration, etc. Mechanistically, TGF-β is secreted in an inactive form and localizes to the extracellular matrix (ECM) via the latent TGF-β binding protein (LTBP). However, it is the release of mature TGF-β that is essential for the activation of the TGF-β signaling pathway. This progress requires specific integrins (one of the main groups of cell adhesion molecules (CAMs)) to recognize and activate the dormant TGF-β. In addition, TGF-β regulates cell adhesion ability through modulating CAMs expression. The aberrant activation of the TGF-β signaling pathway, caused by abnormal expression of key regulatory molecules (such as Smad proteins, certain transcription factors, and non-coding RNAs), promotes tumor invasive and metastasis ability via epithelial-mesenchymal transition (EMT) during the late stages of tumorigenesis. In this paper, we summarize the crosstalk between TGF-β and cell adhesion signaling pathway in cancer and its underlying molecular mechanisms.

Keywords: TGF-β signaling pathway, cell adhesion signaling pathway, cancer

Citation styles

APA
Liao, J., Chen, R., Lin, B., Deng, R., Liang, Y., Zeng, J., Ma, S., Qiu, X. (2024). Cross-Talk between the TGF-β and Cell Adhesion Signaling Pathways in Cancer. International Journal of Medical Sciences, 21(7), 1307-1320. https://doi.org/10.7150/ijms.96274.

ACS
Liao, J.; Chen, R.; Lin, B.; Deng, R.; Liang, Y.; Zeng, J.; Ma, S.; Qiu, X. Cross-Talk between the TGF-β and Cell Adhesion Signaling Pathways in Cancer. Int. J. Med. Sci. 2024, 21 (7), 1307-1320. DOI: 10.7150/ijms.96274.

NLM
Liao J, Chen R, Lin B, Deng R, Liang Y, Zeng J, Ma S, Qiu X. Cross-Talk between the TGF-β and Cell Adhesion Signaling Pathways in Cancer. Int J Med Sci 2024; 21(7):1307-1320. doi:10.7150/ijms.96274. https://www.medsci.org/v21p1307.htm

CSE
Liao J, Chen R, Lin B, Deng R, Liang Y, Zeng J, Ma S, Qiu X. 2024. Cross-Talk between the TGF-β and Cell Adhesion Signaling Pathways in Cancer. Int J Med Sci. 21(7):1307-1320.

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