Predictive Value of CFIm25 Expression in Peripheral Blood Monocytes for Coronary Atherosclerosis

Liu, Meng; Chen, Xiaoxiao; Gu, Zhan; He, Hao; Chen, Mingyue; Kuai, Lin; Jia, Zhiqiang; Li, Yi; Chen, Yizhou; Hong, Mei; Xiao, Fangping

doi:10.7150/ijms.91148

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Int J Med Sci 2024; 21(3):562-570. doi:10.7150/ijms.91148 This issue Cite

Research Paper

Predictive Value of CFIm25 Expression in Peripheral Blood Monocytes for Coronary Atherosclerosis

Meng Liu^*, Xiaoxiao Chen^*, Zhan Gu, Hao He, Mingyue Chen, Lin Kuai, Zhiqiang Jia, Yi Li, Yizhou Chen, Mei Hong^✉, Fangping Xiao^✉

Department of Cardiology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, 210011, China.
* Meng Liu and Xiaoxiao Chen contributed equally.

Citation:

Liu M, Chen X, Gu Z, He H, Chen M, Kuai L, Jia Z, Li Y, Chen Y, Hong M, Xiao F. Predictive Value of CFIm25 Expression in Peripheral Blood Monocytes for Coronary Atherosclerosis. Int J Med Sci 2024; 21(3):562-570. doi:10.7150/ijms.91148. https://www.medsci.org/v21p0562.htm

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Abstract

Background: Cleavage factor Im25 (CFIm25) regulates cell function by affecting mRNA editing processes and plays diverse roles in various diseases. Studies have found that peripheral blood monocytes are valuable in diagnosing and prognosing coronary atherosclerosis. However, no studies have examined the predictive value of CFIm25 expression in peripheral blood monocytes for coronary atherosclerosis.

Methods and Results: We collected the coronary angiography results of 267 patients and calculated the Gensini score to evaluate their degree of coronary atherosclerosis. We isolated peripheral blood monocytes and detected CFIm25 RNA expression. Based on their Gensini score, we divided the patients into negative (0, n = 46), mild lesion (≤ 8, n = 71), moderate lesion (8-23, n = 76), and severe lesion (≥ 23, n = 74) groups. Results showed that CFIm25 expression correlated negatively with the Gensini score and the number of involved coronary vessels. Univariate and multivariate binary logistic regression analyses showed that CFIm25 expression in peripheral blood monocytes was a protective factor for severe lesions, ≥ 50% stenosis, and three-vessel lesions. The areas under the receiver operating characteristic curve of CFIm25 expression for predicting lesions, severe lesions, ≥50% stenosis, and three-vessel lesions were 0.743, 0.735, 0.791, and 0.736, respectively.

Conclusions: CFIm25 expression in peripheral blood monocytes correlates negatively with the degree of coronary atherosclerosis and helps predict the severity and number of coronary artery lesions.

Keywords: cleavage factor Im25, coronary atherosclerosis, peripheral blood monocyte, Gensini score

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APA

Liu, M., Chen, X., Gu, Z., He, H., Chen, M., Kuai, L., Jia, Z., Li, Y., Chen, Y., Hong, M., Xiao, F. (2024). Predictive Value of CFIm25 Expression in Peripheral Blood Monocytes for Coronary Atherosclerosis. International Journal of Medical Sciences, 21(3), 562-570. https://doi.org/10.7150/ijms.91148.

ACS

Liu, M.; Chen, X.; Gu, Z.; He, H.; Chen, M.; Kuai, L.; Jia, Z.; Li, Y.; Chen, Y.; Hong, M.; Xiao, F. Predictive Value of CFIm25 Expression in Peripheral Blood Monocytes for Coronary Atherosclerosis. Int. J. Med. Sci. 2024, 21 (3), 562-570. DOI: 10.7150/ijms.91148.

NLM

CSE

Liu M, Chen X, Gu Z, He H, Chen M, Kuai L, Jia Z, Li Y, Chen Y, Hong M, Xiao F. 2024. Predictive Value of CFIm25 Expression in Peripheral Blood Monocytes for Coronary Atherosclerosis. Int J Med Sci. 21(3):562-570.

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