Prognostic and Clinical Implications of UNC13C expression in Hepatocellular Carcinoma Patients

Kumar, V. Bharath; Lee, Chien-Hsun; Su, Tzu-Cheng; Lin, Chia-Chieh; Mohammedsaleh, Zuhair M.; Yeh, Chung-Min; Kiefer, Rudolf; Lin, Shu-Hui

doi:10.7150/ijms.80488

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Int J Med Sci 2023; 20(9):1235-1239. doi:10.7150/ijms.80488 This issue Cite

Research Paper

Prognostic and Clinical Implications of UNC13C expression in Hepatocellular Carcinoma Patients

V. Bharath Kumar^1*, Chien-Hsun Lee^2,3*, Tzu-Cheng Su^3,4, Chia-Chieh Lin⁵, Zuhair M. Mohammedsaleh⁶, Chung-Min Yeh³, Rudolf Kiefer⁷, Shu-Hui Lin^3,8,9✉

1. Department of Medical Laboratory Science and Biotechnology, Asia University, Taichung, Taiwan.
2. Department of Pathology, E- Da Hospital, I-Shou University, Kaohsiung, Taiwan.
3. Department of Surgical Pathology, Changhua Christian Hospital, Changhua, Taiwan.
4. School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan.
5. Oral Cancer Research Center, Changhua Christian Hospital, Changhua, Taiwan.
6. Department of Medical Laboratory Technology, Faculty of Applies Medical Sciences, University of Tabuk, Tabuk-71491, Kingdom of Saudi Arabia.
7. Conducting Polymers in Composites and Applications Research Group, Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City 758307, Vietnam.
8. Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, Taichung, Taiwan.
9. Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University. Taichung, Taiwan.
* Equal contribution.

Citation:

Kumar VB, Lee CH, Su TC, Lin CC, Mohammedsaleh ZM, Yeh CM, Kiefer R, Lin SH. Prognostic and Clinical Implications of UNC13C expression in Hepatocellular Carcinoma Patients. Int J Med Sci 2023; 20(9):1235-1239. doi:10.7150/ijms.80488. https://www.medsci.org/v20p1235.htm

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Abstract

Aberrant expression of UNC13C (Unc-13 Homolog C) has been observed during the progression of oral squamous cell carcinoma. However, the expression pattern and clinical relevance of UNC13C in Hepatocellular carcinoma (HCC) remain to be elucidated. The purpose of this study is to examine UNC13C expression in HCC and explore its role in clinicopathological factor or prognosis in HCC. Two hundred and sixty-five patients diagnosed with HCC were included in the present study. The expression of UNC13C in HCC tissues was analyzed by immunohistochemistry analysis. The relationship between UNC13C protein and clinicopathological characteristics in HCC was investigated. Moreover, the high expression of UNC13C was significantly correlated with T stage, AJCC stage and overall survival rates. Cox regression analysis identified UNC13C as an independent prognostic indicator for HCC patients. UNC13C might be a prognostic biomarker and therapeutic target in HCC. Further studies with larger sample sets are needed to understand the clinical implications of UNC13C in hepatocellular carcinoma.

Keywords: UNC13C, HCC, prognosis, T stage, survival, independent prognostic

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APA

Kumar, V.B., Lee, C.H., Su, T.C., Lin, C.C., Mohammedsaleh, Z.M., Yeh, C.M., Kiefer, R., Lin, S.H. (2023). Prognostic and Clinical Implications of UNC13C expression in Hepatocellular Carcinoma Patients. International Journal of Medical Sciences, 20(9), 1235-1239. https://doi.org/10.7150/ijms.80488.

ACS

Kumar, V.B.; Lee, C.H.; Su, T.C.; Lin, C.C.; Mohammedsaleh, Z.M.; Yeh, C.M.; Kiefer, R.; Lin, S.H. Prognostic and Clinical Implications of UNC13C expression in Hepatocellular Carcinoma Patients. Int. J. Med. Sci. 2023, 20 (9), 1235-1239. DOI: 10.7150/ijms.80488.

NLM

CSE

Kumar VB, Lee CH, Su TC, Lin CC, Mohammedsaleh ZM, Yeh CM, Kiefer R, Lin SH. 2023. Prognostic and Clinical Implications of UNC13C expression in Hepatocellular Carcinoma Patients. Int J Med Sci. 20(9):1235-1239.

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