ISSN: 1449-1907International Journal of Medical Sciences
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Int J Med Sci 2023; 20(6):818-835. doi:10.7150/ijms.82419 This issue Cite
Review
Regulatory mechanisms and clinical applications of tumor-driven exosomal circRNAs in cancers
Department of Gastric Surgery, Cancer Hospital of China Medical University/Liaoning Cancer Hospital, Shenyang, Liaoning, China
Citation:
Meng X, Yang D, Zhang B, Zhao Y, Zheng Z, Zhang T. Regulatory mechanisms and clinical applications of tumor-driven exosomal circRNAs in cancers. Int J Med Sci 2023; 20(6):818-835. doi:10.7150/ijms.82419. https://www.medsci.org/v20p0818.htm
Other stylesAbstract
Malignant tumors seriously affect people's survival and prognosis. Exosomes, as vesicle structures widely existing in human tissues and body fluids, are involved in cell-to-cell transmission. Tumor-derived exosomes were secreted from tumors and involved in the development of carcinogenesis. Circular RNA (circRNA), a novel member of endogenous noncoding RNAs, is widespread in human and play a vital role in many physiological or pathological processes. Tumor-driven exosomal circRNAs are often involved in tumorigenesis and development including the proliferation, invasion, migration and chemo-or-radiotherapy sensitivity of tumor cell by multiple regulatory mechanisms. In this review, we will elaborate the roles and functions of tumor-driven exosomal circRNAs in cancers which may be used as potential cancer biomarkers and novel therapeutic targets.
Keywords: cancer, tumor-driven exosomes, exosomal circRNAs, mechanisms, clinical application
Citation styles
APA
Meng, X., Yang, D., Zhang, B., Zhao, Y., Zheng, Z., Zhang, T. (2023). Regulatory mechanisms and clinical applications of tumor-driven exosomal circRNAs in cancers. International Journal of Medical Sciences, 20(6), 818-835. https://doi.org/10.7150/ijms.82419.
ACS
Meng, X.; Yang, D.; Zhang, B.; Zhao, Y.; Zheng, Z.; Zhang, T. Regulatory mechanisms and clinical applications of tumor-driven exosomal circRNAs in cancers. Int. J. Med. Sci. 2023, 20 (6), 818-835. DOI: 10.7150/ijms.82419.
NLM
Meng X, Yang D, Zhang B, Zhao Y, Zheng Z, Zhang T. Regulatory mechanisms and clinical applications of tumor-driven exosomal circRNAs in cancers. Int J Med Sci 2023; 20(6):818-835. doi:10.7150/ijms.82419. https://www.medsci.org/v20p0818.htm
CSE
Meng X, Yang D, Zhang B, Zhao Y, Zheng Z, Zhang T. 2023. Regulatory mechanisms and clinical applications of tumor-driven exosomal circRNAs in cancers. Int J Med Sci. 20(6):818-835.
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