Full Text | PDF

Share on tweeters Share on facebook Share on linkedin Share on googleplus

Int J Med Sci 2023; 20(6):717-724. doi:10.7150/ijms.82407 This issue Cite

Research Paper

Synergistic Effect of Metformin and Lansoprazole Against Gastric Cancer through Growth Inhibition

Hsiao-Wei Kao1, Kuo-Wang Tsai3, Wen-chang Lin1,2✉

1. Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, R.O.C.
2. Institute of Biomedical Informatics, National Yang Ming Chiao Tung University, Taipei, Taiwan, R.O.C.
3. Department of Research, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan, R.O.C.

✉ Corresponding author: Wen-chang Lin, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, R.O.C. Tel: 886-2-26523967; E-mail: wenlinsinica.edu.tw.

Citation:
Kao HW, Tsai KW, Lin Wc. Synergistic Effect of Metformin and Lansoprazole Against Gastric Cancer through Growth Inhibition. Int J Med Sci 2023; 20(6):717-724. doi:10.7150/ijms.82407. https://www.medsci.org/v20p0717.htm
Other styles

File import instruction

Abstract

Graphic abstract

Cancer has been linked to metabolic disorders and diverse gene mutations. Metformin, which is widely used to treat type 2 diabetes, inhibits the growth of cancer cells in animal models. Here we investigated the effects of metformin on human gastric cancer cell lines. We also investigated the synergistic anticancer effect of metformin and proton pump inhibitors. Lansoprazole, a proton pump inhibitor, is effective for treating gastroesophageal reflux disease. Our results revealed that metformin and lansoprazole can significantly inhibit cancer cell growth in a dose-dependent manner by suppressing cell cycle progression and inducing apoptosis. Low concentrations of metformin and lansoprazole have a synergistic effect on AGS cell growth inhibition. In summary, our findings suggest a new and safe treatment protocol for treating stomach cancers.

Keywords: Metformin and Lansoprazole, Synergistic Effect, Gastric Cancer

Citation styles

APA
Kao, H.W., Tsai, K.W., Lin, W.c. (2023). Synergistic Effect of Metformin and Lansoprazole Against Gastric Cancer through Growth Inhibition. International Journal of Medical Sciences, 20(6), 717-724. https://doi.org/10.7150/ijms.82407.

ACS
Kao, H.W.; Tsai, K.W.; Lin, W.c. Synergistic Effect of Metformin and Lansoprazole Against Gastric Cancer through Growth Inhibition. Int. J. Med. Sci. 2023, 20 (6), 717-724. DOI: 10.7150/ijms.82407.

NLM
Kao HW, Tsai KW, Lin Wc. Synergistic Effect of Metformin and Lansoprazole Against Gastric Cancer through Growth Inhibition. Int J Med Sci 2023; 20(6):717-724. doi:10.7150/ijms.82407. https://www.medsci.org/v20p0717.htm

CSE
Kao HW, Tsai KW, Lin Wc. 2023. Synergistic Effect of Metformin and Lansoprazole Against Gastric Cancer through Growth Inhibition. Int J Med Sci. 20(6):717-724.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
Popup Image

©2024 Ivyspring International Publisher. Terms of use