Int J Med Sci 2023; 20(3):318-328. doi:10.7150/ijms.80503 This issue Cite

Research Paper

S100A11 Promotes Metastasis via AKT and ERK Signaling Pathways and Has a Diagnostic Role in Hepatocellular Carcinoma

Mei Zheng1, Huan Meng1, Yunhui Li1, Jingren Shi1, Ying Han1, Changxu Zhao2, Jin Chen1, Jinyu Han1, Jing Liang1, Yuan Chen1, Qiqi Liu2✉, Yajie Wang1✉

1. Department of Clinical Laboratory, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China.
2. Beijing Institute of Microbiology and Epidemiology, Beijing, 100850, China.

Citation:
Zheng M, Meng H, Li Y, Shi J, Han Y, Zhao C, Chen J, Han J, Liang J, Chen Y, Liu Q, Wang Y. S100A11 Promotes Metastasis via AKT and ERK Signaling Pathways and Has a Diagnostic Role in Hepatocellular Carcinoma. Int J Med Sci 2023; 20(3):318-328. doi:10.7150/ijms.80503. https://www.medsci.org/v20p0318.htm
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Abstract

Graphic abstract

Hepatocellular carcinoma (HCC) is the most common and malignant liver tumor worldwide, although the treatment approaches for HCC continue to evolve, metastasis is the main reason for high mortality rates. S100 calcium-binding protein A11 (S100A11), an important member of the S100 family of small calcium-binding proteins, is overexpressed in various cells and regulates tumor development and metastasis. However, few studies report the role and underlying regulatory mechanisms of S100A11 in HCC development and metastasis. Herein, we discovered that S100A11 is overexpressed and associated with poor clinical outcomes in HCC cohorts, and we provided the first demonstration that S100A11 could serve as a novel diagnostic biomarker used in conjunction with AFP for HCC. Further analysis implied that S100A11 outperforms AFP in determining whether HCC patients have hematogenous metastasis or not. Using in vitro cell culture model, we demonstrated that S100A11 is overexpressed in metastatic hepatoma cells, knockdown of S100A11 decreases hepatoma cells proliferation, migration, invasion, and epithelial-mesenchymal transition process by inhibiting AKT and ERK signaling pathways. Altogether, our study provides new sights into the biological function and mechanisms underlying S100A11 in promoting metastasis of HCC and explores a novel target for HCC diagnosis and treatment.

Keywords: S100A11, hepatocellular carcinoma, biomarker, metastasis, signaling pathway


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APA
Zheng, M., Meng, H., Li, Y., Shi, J., Han, Y., Zhao, C., Chen, J., Han, J., Liang, J., Chen, Y., Liu, Q., Wang, Y. (2023). S100A11 Promotes Metastasis via AKT and ERK Signaling Pathways and Has a Diagnostic Role in Hepatocellular Carcinoma. International Journal of Medical Sciences, 20(3), 318-328. https://doi.org/10.7150/ijms.80503.

ACS
Zheng, M.; Meng, H.; Li, Y.; Shi, J.; Han, Y.; Zhao, C.; Chen, J.; Han, J.; Liang, J.; Chen, Y.; Liu, Q.; Wang, Y. S100A11 Promotes Metastasis via AKT and ERK Signaling Pathways and Has a Diagnostic Role in Hepatocellular Carcinoma. Int. J. Med. Sci. 2023, 20 (3), 318-328. DOI: 10.7150/ijms.80503.

NLM
Zheng M, Meng H, Li Y, Shi J, Han Y, Zhao C, Chen J, Han J, Liang J, Chen Y, Liu Q, Wang Y. S100A11 Promotes Metastasis via AKT and ERK Signaling Pathways and Has a Diagnostic Role in Hepatocellular Carcinoma. Int J Med Sci 2023; 20(3):318-328. doi:10.7150/ijms.80503. https://www.medsci.org/v20p0318.htm

CSE
Zheng M, Meng H, Li Y, Shi J, Han Y, Zhao C, Chen J, Han J, Liang J, Chen Y, Liu Q, Wang Y. 2023. S100A11 Promotes Metastasis via AKT and ERK Signaling Pathways and Has a Diagnostic Role in Hepatocellular Carcinoma. Int J Med Sci. 20(3):318-328.

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