Int J Med Sci 2023; 20(1):50-56. doi:10.7150/ijms.79496 This issue Cite

Research Paper

Effects of Long-Term Wear and Discontinuation of Orthokeratology Lenses on the Eyeball Parameters in Children with Myopia

Qin Zhu1,2*, Jie Yin2*, Xuejiao Li2*, Min Hu2, Liping Xue2, Jieying Zhang2, Yuan Zhou2, Xiaofan Zhang2, Yingting Zhu3✉, Hua Zhong1✉

1. Department of Ophthalmology, the First Affiliated Hospital of Kunming Medical University, Kunming 650031, China.
2. Department of Pediatric Ophthalmology, Affiliated Hospital of Yunnan University; Kunming 650021, China.
3. BioTissue (Tissue Tech, Inc.), Ocular Surface Center, and Ocular Surface Research & Education Foundation, Miami, FL, 33126 USA.
* The first 3 authors contribute equally for this manuscript.

Citation:
Zhu Q, Yin J, Li X, Hu M, Xue L, Zhang J, Zhou Y, Zhang X, Zhu Y, Zhong H. Effects of Long-Term Wear and Discontinuation of Orthokeratology Lenses on the Eyeball Parameters in Children with Myopia. Int J Med Sci 2023; 20(1):50-56. doi:10.7150/ijms.79496. https://www.medsci.org/v20p0050.htm
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Abstract

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Objective: To evaluate the effects of long-term wear and discontinuation of the orthokeratology lenses (Orth-K) on the biological parameters of eyeballs in children with myopia.

Methods: In this prospective study, a total of 308 subjects with myopia were randomized to receive Orth-K (n = 154) or single vision spectacles (SVS) (n = 154) for 12 months followed by a 1-month withdrawal period. The axial length (AL), the central corneal thickness (CCT), the anterior chamber depth (ACD) and the central lens thickness (CLT) were assessed at the baseline, 6 months, 12 months, and 13 months (1-month after lens withdrawal).

Results: A total of 279 subjects completed the 13-month follow-up (142 in Orth-K group and 137 in SVS group). No statistical difference was noted in AL, CCT, ACD and CLT between the two groups at the baseline (all p > 0.05). However, compared with the baseline, the AL from the two groups became elongated 12 months after wearing Orth-K or SVS. The increase of AL in Orth-K group was 0.22 ± 0.11 mm, significantly smaller than 0.35 ± 0.08 mm in SVS group (p < 0.05). In addition, CCT in Orth-K group was 544.26 ± 11.69 µm at 12 months, significantly thinner than 550.49 ± 12.13 µm in SVS group (p < 0.05). Interestingly, the change in CCT between the baseline and 1-month after withdrawal of the lens was not statistically different in either group (all p > 0.05). Furthermore, at 12-months, CLT in Orth-K group was 3.35 ± 0.21 mm, significantly thicker than 3.31 ± 0.15 mm at baseline and thicker than 3.30 ± 0.05 mm in SVS group at 12 months (all p < 0.05). Lastly, ACD was not statistically different between Orth-K and SVS groups at any time point (p > 0.05).

Conclusion: Orthokeratology lenses can effectively retard axial elongation, reversibly reduce CCT, increase CLT in myopic children, but have no obvious effect on ACD, indicating that Orth-K may significantly retard myopia without noticeable myopia rebound after interruption of Orth-K.

Keywords: myopia, children, orthokeratology, axial length, central corneal thickness, anterior chamber depth, central lens thickness


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APA
Zhu, Q., Yin, J., Li, X., Hu, M., Xue, L., Zhang, J., Zhou, Y., Zhang, X., Zhu, Y., Zhong, H. (2023). Effects of Long-Term Wear and Discontinuation of Orthokeratology Lenses on the Eyeball Parameters in Children with Myopia. International Journal of Medical Sciences, 20(1), 50-56. https://doi.org/10.7150/ijms.79496.

ACS
Zhu, Q.; Yin, J.; Li, X.; Hu, M.; Xue, L.; Zhang, J.; Zhou, Y.; Zhang, X.; Zhu, Y.; Zhong, H. Effects of Long-Term Wear and Discontinuation of Orthokeratology Lenses on the Eyeball Parameters in Children with Myopia. Int. J. Med. Sci. 2023, 20 (1), 50-56. DOI: 10.7150/ijms.79496.

NLM
Zhu Q, Yin J, Li X, Hu M, Xue L, Zhang J, Zhou Y, Zhang X, Zhu Y, Zhong H. Effects of Long-Term Wear and Discontinuation of Orthokeratology Lenses on the Eyeball Parameters in Children with Myopia. Int J Med Sci 2023; 20(1):50-56. doi:10.7150/ijms.79496. https://www.medsci.org/v20p0050.htm

CSE
Zhu Q, Yin J, Li X, Hu M, Xue L, Zhang J, Zhou Y, Zhang X, Zhu Y, Zhong H. 2023. Effects of Long-Term Wear and Discontinuation of Orthokeratology Lenses on the Eyeball Parameters in Children with Myopia. Int J Med Sci. 20(1):50-56.

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