ISSN: 1449-1907International Journal of Medical Sciences
Global reach, higher impact
Int J Med Sci 2022; 19(14):2058-2070. doi:10.7150/ijms.76694 This issue Cite
Review
Role of CXCL10 in Spinal Cord Injury
1. Wuxi School of Medicine, Jiangnan University, Wuxi 214122, Jiangsu, China
2. Department of Pathogen Biology, Guizhou Nursing Vocational College, Guiyang, China
3. Cell Biology Department, Wuxi School of Medicine, Jiangnan University, Wuxi 214122, Jiangsu, China
#These authors contributed equally to this article
Abstract
Spinal cord injury (SCI) results in acute inflammatory responses and secondary damages, including neuronal and glial cell death, axonal damage and demyelination, and blood-brain barrier (BBB) damage, eventually leading to neuronal dysfunction and other complications. C-X-C motif Chemokine Ligand 10 (CXCL10) is expressed after the injury, playing multiple roles in the development and progression of SCI. Moreover, the CXCL10 antagonist can restrict inflammatory immune responses and promote neuronal regeneration and functional recovery. In this review, we summarize the structure and biological functions of CXCL10, and the roles of the CXCL10 / CXCR3 axis in acute inflammatory responses, secondary damages, and complications during SCI, thus providing a potential theoretical basis by highlighting CXCL10 as a new potential drug target for the treatment of SCI.
Keywords: CXCL10, Spinal cord injury (SCI), CXCR3, Inflammatory, Secondary damage, Complications
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