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Int J Med Sci 2022; 19(14):2033-2043. doi:10.7150/ijms.74713 This issue Cite

Review

CircRNAs in hepatocellular carcinoma: characteristic, functions and clinical significance

Yujun Zhou1, Xingkang Mao2, Rui Peng3, Dousheng Bai3✉

1. Department of Hepatobiliary and Pancreatic Surgery, Huaihua First People's Hospital, Huaihua, Hunan, P. R. China.
2. Cardiovascular Center, Huizhou First Municipal People's Hospital, Huizhou, Guangdong, P. R. China.
3. Department of Hepatobiliary Surgery, Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu, P. R. China.

✉ Corresponding author: Dousheng Bai, Department of Hepatobiliary Surgery, Clinical Medical College, Yangzhou University, 98 West Nantong Road, Yangzhou, Jiangsu, P.R.China. E-mail: drbaidoushengedu.cn.

Citation:
Zhou Y, Mao X, Peng R, Bai D. CircRNAs in hepatocellular carcinoma: characteristic, functions and clinical significance. Int J Med Sci 2022; 19(14):2033-2043. doi:10.7150/ijms.74713. https://www.medsci.org/v19p2033.htm
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Abstract

Graphic abstract

Hepatocellular carcinoma (HCC) is one of the most common and serious types of cancer worldwide, with high incidence and mortality rates. Circular RNAs (circRNAs) are a novel class of non-coding RNA with important biological functions. In recent years, multiple circRNAs have been found to be involved in the biological processes of tumorigenesis and tumor development. Increasing evidence has shown that circRNAs also play a crucial role in the occurrence and development of HCC. However, the specific molecular mechanism of circRNAs in HCC has not been fully elucidated. The present review systematically summarized the classification and basic characteristics of circRNAs, their biological functions and their role in the occurrence and development of HCC. By summarizing the previous studies on circRNAs in HCC, this study aimed to indicate potential approaches to improving the early diagnosis and treatment of HCC.

Keywords: hepatocellular carcinoma, circRNAs, molecular sponge, circRNA-miRNA-mRNA axis

Citation styles

APA
Zhou, Y., Mao, X., Peng, R., Bai, D. (2022). CircRNAs in hepatocellular carcinoma: characteristic, functions and clinical significance. International Journal of Medical Sciences, 19(14), 2033-2043. https://doi.org/10.7150/ijms.74713.

ACS
Zhou, Y.; Mao, X.; Peng, R.; Bai, D. CircRNAs in hepatocellular carcinoma: characteristic, functions and clinical significance. Int. J. Med. Sci. 2022, 19 (14), 2033-2043. DOI: 10.7150/ijms.74713.

NLM
Zhou Y, Mao X, Peng R, Bai D. CircRNAs in hepatocellular carcinoma: characteristic, functions and clinical significance. Int J Med Sci 2022; 19(14):2033-2043. doi:10.7150/ijms.74713. https://www.medsci.org/v19p2033.htm

CSE
Zhou Y, Mao X, Peng R, Bai D. 2022. CircRNAs in hepatocellular carcinoma: characteristic, functions and clinical significance. Int J Med Sci. 19(14):2033-2043.

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