Int J Med Sci 2022; 19(8):1357-1363. doi:10.7150/ijms.73150 This issue

Review

Research Progress in the Medical Application of Heavy Water, Especially in the Field of D2O-Raman Spectroscopy

Xin Wang, Nai-meng Liu, Ya-fei Zhao, Fan Yang, Zi-jia Zhu, Dong Song

Department of Breast Surgery, First Hospital of Jilin University, Changchun, Jilin 130021

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Citation:
Wang X, Liu Nm, Zhao Yf, Yang F, Zhu Zj, Song D. Research Progress in the Medical Application of Heavy Water, Especially in the Field of D2O-Raman Spectroscopy. Int J Med Sci 2022; 19(8):1357-1363. doi:10.7150/ijms.73150. Available from https://www.medsci.org/v19p1357.htm

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Abstract

Graphic abstract

Heavy water is an ideal contrast agent for metabolic activity and can be adapted to a wide range of biological systems owing to its non-invasiveness, universal applicability, and cost-effectiveness. As a new type of probe, the heavy isotope of water has been widely used in the study of cell development, metabolism, tissue homeostasis, aging, and tumor heterogeneity. Herein, we review findings supporting the applications of and research on heavy water in monitoring of bacterial metabolism, rapid detection of drug sensitivity, identification of tumor cells, precision medicine, and evaluation of skin barrier function and promote the use of heavy water as a suitable marker for the development of detection and treatment methodologies.

Keywords: heavy water, deuterium oxide, Raman microspectroscopy, isotypes, probe, medicine.