Int J Med Sci 2022; 19(6):1023-1028. doi:10.7150/ijms.71931 This issue Cite

Research Paper

Analysis of EZH2 Genetic Variants on Triple-Negative Breast Cancer Susceptibility and Pathology

Liang-Chih Liu1,2#, Yi-Chung Chien3,4,5,6,7#, Guo-Wei Wu3,7, Chun-Hung Hua8, I-Chen Tsai3,9, Chih-Chiang Hung9,10, Tsai-Kun Wu11,12, Ying-Ru Pan13, Shun-Fa Yang14,15✉, Yung-Luen Yu3,4,5,6,7,16✉

1. School of Medicine, College of Medicine, China Medical University, Taichung 40402, Taiwan
2. Department of Surgery, China Medical University Hospital, Taichung 40402, Taiwan
3. Graduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan
4. Ph.D. Program for Translational Medicine, China Medical University, Taichung 40402, Taiwan
5. Institute of New Drug Development, China Medical University, Taichung 40402, Taiwan
6. Drug Development Center, Research Center for Cancer Biology, China Medical University, Taichung 40402, Taiwan
7. Center for Molecular Medicine, China Medical University Hospital, Taichung 40402, Taiwan
8. Department of Otorhinolaryngology Head and Neck Surgery, China Medical University Hospital, Taichung 40402, Taiwan
9. Division of Breast Surgery, Department of Surgery, Taichung Veterans General Hospital, Taichung 40705, Taiwan
10. Department of Applied Cosmetology, College of Human Science and Social Innovation, Hungkuang University, Taichung 43302, Taiwan
11. Division of Renal Medicine, Tungs' Taichung MetroHarbor Hospital, Taichung 43503, Taiwan
12. College of Medicine, National Chung Hsing University, Taichung 402204, Taiwan
13. Department of Medical Research, Tungs' Taichung Metroharbor Hospital, Taichung, Taiwan
14. Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
15. Department of Medical Research, Chung Shan Medical University Hospital, Taichung 40201, Taiwan
16. Department of Medical Laboratory Science and Biotechnology, Asia University, Taichung 41354, Taiwan
#Equal contributions to this work.

Citation:
Liu LC, Chien YC, Wu GW, Hua CH, Tsai IC, Hung CC, Wu TK, Pan YR, Yang SF, Yu YL. Analysis of EZH2 Genetic Variants on Triple-Negative Breast Cancer Susceptibility and Pathology. Int J Med Sci 2022; 19(6):1023-1028. doi:10.7150/ijms.71931. https://www.medsci.org/v19p1023.htm
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Abstract

Graphic abstract

Triple-negative breast cancer (TNBC) is the third most common female cancer in Taiwan. EZH2 plays an important role in cancer development through transcriptional repression by chromatin remodeling. However, the expression of EZH2 in breast cancer is highly correlated with tumorigenesis, and patient survival is not matched to TNBC. Furthermore, it has not been determined if specific EZH2 genetic variants are associated with breast cancer risk. In this paper, we evaluated the survival of different types of breast cancer. The results indicated that a lower expression of EZH2 led to poor survival of TNBC patients. Therefore, we aimed at studying the relationship between genetic polymorphisms of EZH2 and susceptibility to TNBC in Taiwan. Four single-nucleotide polymorphisms (SNPs) of EZH2 (rs6950683, rs2302427, rs3757441, and rs41277434) were analyzed by real-time PCR genotyping in 176 patients with TNBC and 1000 cancer-free controls. The results showed that TNBC patients under 60 years old who carried a TC or CC genotype at EZH2 rs6950683 and re3757441 had a tumor size of 20 mm or smaller (T1). Thus, this study is the first to examine the age and mutant genes associated with EZH2 SNPs in TNBC progression and development in Taiwan.

Keywords: EZH2, triple-negative breast cancer, single-nucleotide polymorphism (SNP), age


Citation styles

APA
Liu, L.C., Chien, Y.C., Wu, G.W., Hua, C.H., Tsai, I.C., Hung, C.C., Wu, T.K., Pan, Y.R., Yang, S.F., Yu, Y.L. (2022). Analysis of EZH2 Genetic Variants on Triple-Negative Breast Cancer Susceptibility and Pathology. International Journal of Medical Sciences, 19(6), 1023-1028. https://doi.org/10.7150/ijms.71931.

ACS
Liu, L.C.; Chien, Y.C.; Wu, G.W.; Hua, C.H.; Tsai, I.C.; Hung, C.C.; Wu, T.K.; Pan, Y.R.; Yang, S.F.; Yu, Y.L. Analysis of EZH2 Genetic Variants on Triple-Negative Breast Cancer Susceptibility and Pathology. Int. J. Med. Sci. 2022, 19 (6), 1023-1028. DOI: 10.7150/ijms.71931.

NLM
Liu LC, Chien YC, Wu GW, Hua CH, Tsai IC, Hung CC, Wu TK, Pan YR, Yang SF, Yu YL. Analysis of EZH2 Genetic Variants on Triple-Negative Breast Cancer Susceptibility and Pathology. Int J Med Sci 2022; 19(6):1023-1028. doi:10.7150/ijms.71931. https://www.medsci.org/v19p1023.htm

CSE
Liu LC, Chien YC, Wu GW, Hua CH, Tsai IC, Hung CC, Wu TK, Pan YR, Yang SF, Yu YL. 2022. Analysis of EZH2 Genetic Variants on Triple-Negative Breast Cancer Susceptibility and Pathology. Int J Med Sci. 19(6):1023-1028.

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