Int J Med Sci 2022; 19(5):952-964. doi:10.7150/ijms.62438 This issue Cite

Research Paper

In situ scarless skin healing of a severe human burn wound induced by a hCTLA4Ig gene-transferred porcine skin graft

Lijun Zhang1,2,#, Guangchao Xu1,#, Yating Wei1, Mingzhou Yuan2, Yuanyuan Li1,2, Meifang Yin1,2, Chufen Chen2, Guangtao Huang1, Bin Shu2,✉, Jun Wu1,2,3✉

1. Department of Burns and Plastic Surgery, the First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, P.R. China.
2. Department of Burns, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, P.R. China.
3. Human Histology & Embryology Section, Department of Surgery, Dentistry, Pediatrics & Gynecology, University of Verona Medical School, Italy.
# Equal contribution.

Citation:
Zhang L, Xu G, Wei Y, Yuan M, Li Y, Yin M, Chen C, Huang G, Shu B, Wu J. In situ scarless skin healing of a severe human burn wound induced by a hCTLA4Ig gene-transferred porcine skin graft. Int J Med Sci 2022; 19(5):952-964. doi:10.7150/ijms.62438. https://www.medsci.org/v19p0952.htm
Other styles

File import instruction

Abstract

Graphic abstract

Preventing fibrosis or hypertrophic scar formation following tissue damage is still a big challenge despite the numerous approaches clinicians currently use. Hitherto, no written account was available of a successful case of scarless skin healing after a severe burn injury. Here, we report the first case of the “perfect regenerative healing” of a severe burn wound with no hypertrophic scar formation in which a postage stamp skin autograft was covered with human cytotoxic-T-lymphocyte associated antigen4-immunoglobulin (hCTLA4Ig) gene-transferred pig skin. We also discuss the mechanisms involved in the scarless healing of human burn wounds.


Citation styles

APA
Zhang, L., Xu, G., Wei, Y., Yuan, M., Li, Y., Yin, M., Chen, C., Huang, G., Shu, B., Wu, J. (2022). In situ scarless skin healing of a severe human burn wound induced by a hCTLA4Ig gene-transferred porcine skin graft. International Journal of Medical Sciences, 19(5), 952-964. https://doi.org/10.7150/ijms.62438.

ACS
Zhang, L.; Xu, G.; Wei, Y.; Yuan, M.; Li, Y.; Yin, M.; Chen, C.; Huang, G.; Shu, B.; Wu, J. In situ scarless skin healing of a severe human burn wound induced by a hCTLA4Ig gene-transferred porcine skin graft. Int. J. Med. Sci. 2022, 19 (5), 952-964. DOI: 10.7150/ijms.62438.

NLM
Zhang L, Xu G, Wei Y, Yuan M, Li Y, Yin M, Chen C, Huang G, Shu B, Wu J. In situ scarless skin healing of a severe human burn wound induced by a hCTLA4Ig gene-transferred porcine skin graft. Int J Med Sci 2022; 19(5):952-964. doi:10.7150/ijms.62438. https://www.medsci.org/v19p0952.htm

CSE
Zhang L, Xu G, Wei Y, Yuan M, Li Y, Yin M, Chen C, Huang G, Shu B, Wu J. 2022. In situ scarless skin healing of a severe human burn wound induced by a hCTLA4Ig gene-transferred porcine skin graft. Int J Med Sci. 19(5):952-964.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.